PREPARATION OF A CHIRAL BUILDING BLOCK BASED ON 1,3-SYN-DIOL USING PSEUDOMONAS FLUORESCENSE LIPASE AND ITS APPLICATION TO THE SYNTHESIS OF A HUNGER MODULATOR
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概要
- 論文の詳細を見る
A novel, chiral building block (9) consisting of 1,3-syn-diol was obtained by highly enantioselective hydrolysis of the meso-diacetate (8) with Pseudomonas fluorescens lipase (PFL), and (-)-9 was used to synthesize one of four possible stereoisomers of 2-hydroxy-4-hydroxymethyl-4-butanolide, which has hunger modulating activities.
- 公益社団法人日本薬学会の論文
- 1989-06-25
著者
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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謝 卓峰
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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謝 卓峰
九大・薬
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