Asymmetric Synthesis of (+)-and (-)-Batyl Alcohol, a Key Synthetic Intermediate for Platelet-Activating Factor, by Using Biocatalysts(Organic,Chemical)

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概要

• 論文の詳細を見る

• Asymmetric synthesis of platelet-activating factor (PAF) and its enantiomer by using biocatalysts was studied. Microbial reduction of the pro-chiral α-ketoester (3) afforded (+)-4 (>99% ee), which could be converted to (+)- and (-)-batyl alcohol (12), a key synthetic intermediate for PAF. Compound (-)-4 (96% ee), with the requisite configuration for the synthesis of natural PAF, could also be obtained by enzyme-catalyzed enantioselective hydrolysis or (±)-15.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• 酒井 浄

  Faculty Of Pharmaceutical Sciences Kyushu University

• Oishi T

  Riken Inst. The Inst. Physical And Chemical Research Saitama Jpn

• Akita H

  Inst. Physical And Chemical Research

• Akita Hiroyuki

  Riken Institute

• Oishi Takeshi

  Riken Institute (the Institute Of Physical And Chemical Research) Synthetic Organic Chemistry Labora

• SUEMUNE HIROSHI

  Faculty of Pharmaceutical Sciences, Kyushu Uinversity

• MIZUHARA YUKAKO

  Faculty of Pharmaceutical Sciences, Kyushu University

• AKITA HIROYUKI

  The Institute of Physical and Chemical Research (Riken)

• OISHI TAKESHI

  The Institute of Physical and Chemical Research (Riken)

• SAKI KIYOSHI

  Faculty of Pharmaceutical Sciences, Kyushu University

• Suemune Hiroshi

  Faculty Of Pharmaceutical Sciences Kyushu Uinversity

• Mizuhara Y

  Kyushu Univ. Fukuoka Jpn

• OISHI Takeshi

  The Institute of Physical and Chemical Research

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