Formal Syntheses of (-)-α- and (+)-β-Cuparenones, Cuparene, and Laurene
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概要
- 論文の詳細を見る
This paper describes formal syntheses of the title compounds from the easily prepared chiral synthon (+)-5. One of the structural features of the cuparene family is the presence of vicinal quaternary carbons on the five-membered ring. The quaternary carbon with the tolyl function could be constructed by stereoselective 1,4-addition of (p-tolyl)_2 Zn to(+)-5. The key intermediate β-ketol (13), obtained from (+)-5 via a sequence of reactions, was successfully applied to formal syntheses of the title compounds.
- 公益社団法人日本薬学会の論文
- 1988-04-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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岡野 耕二
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
九州大学薬学部
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岡野 耕二
Life Science Research Laboratory Japan Tobacco Inc.
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末宗 洋
九州大学大学院薬学府
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末宗 洋
九州大学大学院薬学研究院
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