Syntheses of Morphine-like Structures. II. 2'-Methoxy-9-hydroxymethyl-2,5-dimethyl-6,7-benzomorphan
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概要
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dl-2'-Methoxy-9β-hydroxymethyl-2,5-dimethyl-6,7-benzomorphan was synthesized by hydroboration of 2'-methoxy-9-methylene-2,5-dimethyl-6,7-benzomorphan. The β-orientation of the hydroxymethyl group was established by converting IV to the known 9β-methyl derivative. Dehydration of 2'-methoxy-9-hydroxy-2,5,9-trimetyl-6,7-benzomorphan (I) to the 9-methylene derivative (II) produced also a rearrangement product isomeric with II.
- 公益社団法人日本薬学会の論文
- 1964-10-25
著者
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武田 幹男
Osaka Research Laboratory, Tanabe Seiyaku Co., Ltd.
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釘田 博至
Osaka Research Laboratory, Tanabe Seiyaku Co., Ltd.
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釘田 博至
田辺製薬有機研究所
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武田 幹男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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釘田 博至
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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釘田 博至
Osaka Research Laboratory Gohei Tanabe & Co. Ltd.
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武田 幹男
田辺製薬株式会社有機化学研究所
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