Synthesis of 1,5-Benzothiazepine Derivatives. I
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概要
- 論文の詳細を見る
Reaction of 2-aminothiophenols and phenylglicidic esters gave 2-hydroxy-3- (2-aminophenylthio) -3-phenyl-propionic esters (VI) and 2-phenyl-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4 (5H) -ones (VII). Hydrolysis of the amino esters (VI) to the amino carboxylic acids (VIII) and cyclization of the amino acids gave satisfactory yield of the cyclic amides (VII). Reaction of 2-nitrothiophenols (XII) and phenylglicidic esters (V) was also studied. Rearrangement of VIIa to 2-benzilidene-3-keto-benzothiazine (XV) was presented.
- 公益社団法人日本薬学会の論文
- 1970-10-25
著者
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井上 博純
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd, .
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釘田 博至
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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竹尾 聰
田辺製薬株式会社有機化学研究所
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池崎 宗克
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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竹尾 聰
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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釘田 博至
田辺製薬有機研究所
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釘田 博至
Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.
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井上 博純
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd .
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釘田 博至
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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