Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XI. Synthesis of N-Methyl-6-aza-des-N-morphinan (2-Methyl-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [h] isoquinoline).
スポンサーリンク
概要
- 論文の詳細を見る
Synthesis of a morphinan analog in which the ring nitrogen was transposed to 6-position has been described. A benzyl group was introduced into 5-position of 5,6,7,8-tetrahydroisoquinoline, whose methohalide was reduced to the octahydroisoquinoline, and the objective compound was obtained by heating the latter in hydrobromic acid to effect rearrangement-cyclization.
- 社団法人日本薬学会の論文
- 1957-02-20
著者
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大城 進
Osaka Research Laboratory Gohei Tanabe & Co. Ltd.
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斉藤 清一
田辺製薬研
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杉本 典夫
Osaka Research Laboratory Tanabe Seiyaku Co. Ltd.
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釘田 博至
Osaka Research Laboratory, Tanabe Seiyaku Co., Ltd.
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斎藤 清一
Osaka Research Laboratory, Gohei Tanabe & Co., Ltd.
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杉本 典夫
Osaka Research Laboratory Gohei Tanabe & Co. Ltd.
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釘田 博至
Osaka Research Laboratory Tanabe Seiyaku & Co. Ltd.
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釘田 博至
Osaka Research Laboratory Gohei Tanabe & Co. Ltd.
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- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XII. Synthesis of N-Methyl-7-aza-des-N-morphinan (3-Methyl-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [f] isoquinoline).
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- Securinineの構造
- Synthesis of N-Substituted C-Normorphinans and Their Pharmacological Properties
- 15.Securitinine及びSecurinol Aの構造
- Structures of Norsecurinine and Dihydronorsecurinine
- Absolute Stereochemistry at C_ of Norsecurinine and Dihydronorsecurinine
- Structure and Stereochemistry of Norsecurinine and Dihydronorsecurinine
- 18.NorsecurinineおよびVirosineの構造
- Studies on the Synthetic Analgesics. XVII. Syntheses of 2-(N-tert-Aminoalkylacylamino) thiophene.
- A New Method for Preparation of Alkylnitriles from Alkyl Halide and Alkylammonium Cyanide.
- Azabicycloalkanes as Analgetics. I. Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
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- Azabicycloalkanes as Analgetics. IV. 4-Phenyl-2-azabicyclo [2,2,1] heptanes
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- 合成鎮痛剤の研究-3-
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- Syntheses of Morphine-like Structures. II. 2'-Methoxy-9-hydroxymethyl-2,5-dimethyl-6,7-benzomorphan
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- 3-Hydroxy-N-methyl-4b, 8a-methanoiminomethano-4b, 5,6,7,8,8a, 9,10-octahydrophenanthreneの合成(鎮痛剤としてのHydro化Quinoline類及びIsoquinoline類の合成研究第7報)
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