Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XIII. Synthesis of 3-Hydroxy-N-methyl-6-aza-des-N-morphinan (N-Methyl-9-hydroxy-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [h] isoquinoline).
スポンサーリンク
概要
- 論文の詳細を見る
3-Hydroxy-N-methyl-6-aza-des-N-morphinan was synthesized in accordance with the methods described earlier but the compound failed to show any analgesic activity. However, it had antitussive action somewhat weaker than that of codeine.
- 社団法人日本薬学会の論文
- 1957-08-20
著者
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大城 進
Osaka Research Laboratory Gohei Tanabe & Co. Ltd.
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杉本 典夫
Osaka Research Laboratory Tanabe Seiyaku Co. Ltd.
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杉本 典夫
Osaka Research Laboratory Gohei Tanabe & Co. Ltd.
関連論文
- The Preparative and Pharmacological Studies of levo and dextro 9-Aza-des-N-morphinan (2,3,4,4a-Tetrahydro-1H, 6H-5,10b-propanophenanthridin-9-ol).
- Expectorant Effect and Clinical Efficacy of 1-Methyl-3-(di-2-thienylmethylene)piperidine Citrate (AT-327)
- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XV. Synthesis of 3-Hydroxy-N-methyl-7-aza-des-N-morphinan (9-Hydroxy-3-methyl-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [f] isoquinoline).
- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XIV. Synthesis of 6-Hydroxy-4a, 10-trimethylene-1,2,3,4,4a, 9,10,10a-octahydrophenanthridine (Supplement).
- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XIII. Synthesis of 3-Hydroxy-N-methyl-6-aza-des-N-morphinan (N-Methyl-9-hydroxy-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [h] isoquinoline).
- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XII. Synthesis of N-Methyl-7-aza-des-N-morphinan (3-Methyl-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [f] isoquinoline).
- Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XI. Synthesis of N-Methyl-6-aza-des-N-morphinan (2-Methyl-5,10b-trimethylene-1,2,3,4,4a, 5,6,10b-octahydrobenzo [h] isoquinoline).
- 鎮痛剤としてのHydro化Quinoline類及びIsoquinoline類の合成研究(第9報)3-Hydroxy-N-methyl-16-aza-des-N-morphinanの合成(3-Hydroxy-N-methyl-4b, 9-methanoimino-methano-4b, 5,6,7,8,8a, 9,10-Octahydrophenanthrene)
- 鎮痛剤としてのHydro化Quinoline類及びIsoquinoline類の合成研究(第8報)N-Methyl-16-aza-des-N-morphinanの合成(N-Methyl-4b, 9-methanoiminomethano-4b, 5,6,7,8,8a-9,10-octahydrophenanthrene)
- Syntheses of p-Nitrophenyl Ketones. IV. : Preparation of Some p-Nitrophenyl Alkyl Ketone Derivatives by the Starkey Reaction.
- Structures of Norsecurinine and Dihydronorsecurinine
- Absolute Stereochemistry at C_ of Norsecurinine and Dihydronorsecurinine
- Structure and Stereochemistry of Norsecurinine and Dihydronorsecurinine
- Studies on the Synthetic Analgesics. XVII. Syntheses of 2-(N-tert-Aminoalkylacylamino) thiophene.
- A New Method for Preparation of Alkylnitriles from Alkyl Halide and Alkylammonium Cyanide.
- 合成鎮痛剤の研究-3-
- ピペリヂルカルピノール類の合成研究-1・2-