Suppressive Effect of Cycloheximide Cinnamates on Immune Response and Tumor Growth in Mice-A Structure-activity Relationship with Respect to the Substituent on the Benzene Ring of the Cinnamic Acid Moiety

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概要

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• The immunosuppressive and tumor-inhibitory activities in mice of cycloheximide cinnamates depended on the structure and position of a substituent on the benzene ring of the cinnamate moiety. When the levels of antibody production and tumor growth rate in the treated mice were analyzed statistically in relation to Hansch's hydrophobic constant π for each substituent, the π-response curves for the two biological responses were found to be similar to each other, suggesting that the two pharmacological activities depend on a common process which is influenced by the hydrophobicity of the cycloheximide cinnamates.

• 公益社団法人日本薬学会の論文
• 1977-01-25

著者

• 黒葛原 啓

  Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 黒葛原 啓

  R & D Planning Division Tanabe Seiyaku Co. Ltd.

• Tsuzurahara K

  R & D Planning Division Tanabe Seiyaku Co. Ltd.

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• Suppressive Effect of Cycloheximide Cinnamates on Immune Response and Tumor Growth in Mice-A Structure-activity Relationship with Respect to the Substituent on the Benzene Ring of the Cinnamic Acid Moiety

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