50 不斉アミノ環化反応を利用する含窒素生物活性物質の合成(口頭発表の部)
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Sharpless reaction of racemic N-tert-butoxycarbonyl- and N-benzyloxycarbonyl-3-hydroxy-4-pentenylamines (1) and (2) leads to both an asymmetric kinetic resolution to provide optically active 1 and 2, which was subsequently used for intramolecular amidomercuration, and asymmetric epoxidation followed by concomitant cyclization into optically active cis-3-hydroxy-2-hydroxymethylpyrrolidines (4 and 6). Optically active 1,2,4, and 6 have been expediently used as chiral building blocks in the asymmetric synthesis of several biologically active nitrogen-containing products (detoxinine, anisomycin, 3-hydroxygulutamic acid, artficial galantinic acid, 1-hydroxyindolizidines, and indolizidinediol)
- 天然有機化合物討論会の論文
- 1990-09-25
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