Preparation and Pharmacological Evaluation of 4-(1,4-Benzpouinon-2-yl)-4-phenylbutanamides as Potantial Cerebral Protective Agents^1)

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概要

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• A new series of 4-(1,4-benzoquinon-2-yl)-4-phenylbutanamides (2) were synthesized for evaluation of their pharmacological activities. All these compounds sythesized showed singnificant antilipidperoxidation (ALP) activities with brain homogenate in rats and some of them possessed a protective effect against hypobaric hypoxia in mice.Especially, a thiomopholine derivative (21,SUN-4757) showed a wide efficacy spectrum to a variety of experimental screening assays designed for cerebral protective agents, and it had a high LD_<50> value.

• 1992-09-25

著者

• 鈴木 賢治

  Suntory Institute For Biomedical Research Wakayamadai

• 堀川 佳子

  Suntory Institute For Biomedical Research Wakayamadai

• 石原 高文

  Suntory Institute for Biomedical Research

• 宮野 成二

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 佐藤 文夫

  Suntory Institute For Biomedical Research Wakayamadai

• 立岡 敏雄

  Suntory Institute for Biomedical Research, Wakayamadai

• 今尾 佳代子

  Suntory Institute for Biomedical Research, Wakayamadai

• 弘津 一郎

  Suntory Institute for Biomedical Research, Wakayamadai

• 木原 哲郎

  Suntory Institute for Biomedical Research, Wakayamadai

• 八田 瑞穂

  Suntory Institute for Biomedical Research, Wakayamadai

• 堀川 義子

  Suntory Institute for Biomedical Research, Wakayamadai

• 須本 國弘

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 石原 高文

  Suntory Institute For Biomedical Research Wakayamadai

• 木原 哲郎

  Suntory Institute For Biomedical Research Wakayamadai

• 今尾 佳代子

  Suntory Institute For Biomedical Research Wakayamadai

• 立岡 敏雄

  Suntory Institute For Biomedical Research Wakayamadai

• 弘津 一郎

  Suntory Institute For Biomedical Research Wakayamadai

• 須本 國弘

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 宮野 成二

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 八田 瑞穂

  Suntory Institute For Biomedical Research Wakayamadai

関連論文

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• A FORMAL TOTAL SYNTHESIS OF (±)-QUADRONE
• Preparation and Pharmacological Evaluation of 4-(1,4-Benzpouinon-2-yl)-4-phenylbutanamides as Potantial Cerebral Protective Agents^1)
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