Reduction of Five-Membered α, β-Unsaturated Lactones and Related Compounds with the Ni^<2+>/BH^-_4 System
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概要
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The reductions of an α, β-unsaturated lactone (5) and lactam (7) with the Ni^<2+>/BH^-_4 system resulted in the formation of cis-hydrogenated products (8a and 9a) with high stereoselectivity. The cis products (8a and 9a) were easily isomerized to the corresponding trans isomers (8b and 9b, respectively) by refluxing with sodium methoxide in anhydrous methanol. Isotope labeling studies with methyl cinnamate as the substrate indicated that the reduction with this reducing system poceeds stepwise via a carbon-nickel intermediate.
- 公益社団法人日本薬学会の論文
- 1991-05-25
著者
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宮野 成二
Faculty of Pharmaceutical Sciences, Fukuoka University
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須本 國弘
Faculty of Pharmaceutical Sciences, Fukuoka University
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安倍 宣博
Faculty Of Pharmaceutical Sciences Fukuoka University
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藤崎 文子
Faculty of Pharmaceutical Sciences, Fukuoka University
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藤崎 文子
Faculty Of Pharmaceutical Sciences Fukuoka University
-
須本 國弘
Faculty Of Pharmaceutical Sciences Fukuoka University
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宮野 成二
Faculty Of Pharmaceutical Sciences Fukuoka University
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