Synthesis of Novel 2-Chloro-1,4-dihydropyridines by Chlorination of 2-Hydroxy-1,4-dihydropyridines with Phosphorus Oxychloride

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概要

• 論文の詳細を見る

• Novel 2-chloro-1,4-dihydropyridine derivatives were synthesized by chlorination of 2-hydroxy-1,4-dihydropyridines with POCl_3. The dihydropyridines chlorinated at position 2 exhibited more potent vasodilative and hypotensive activities than the dihydropyridines (nicardipine and nitrendipine) with a methyl group at position 2.

• 社団法人日本薬学会の論文
• 1989-08-25

著者

• 水野 章

  Suntory Institute For Biomedical Research

• 相坂 一雄

  Suntory Institute For Biomedical Research

• 長 秀連

  Suntory Institute for Biomedical Research

• 植田 勝

  Suntory Institute for Biomedical Research

• 石原 高文

  Suntory Institute for Biomedical Research

• 野口 照久

  Suntory Institute for Biomedical Research

• 石原 高文

  Suntory Institute For Biomedical Research Wakayamadai

関連論文

• Synthesis of Novel 2-Chloro-1,4-dihydropyridines by Chlorination of 2-Hydroxy-1,4-dihydropyridines with Phosphorus Oxychloride
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