TRANSFORMATION OF PROTOBERBERINES INTO BENZINDENOAZEPINES A TOTAL SYNTHESIS OF FUMAROFINE AND O-METHYLFUMAROFINE

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概要

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• Acidic treatment of the 8,14-cycloberbine (12), derived from the protoberberine (8), effected regioselective ring cleavage to afford the cis-benzindenoazepine (15) along with a small amount of the trans-derivative (16) after N-methylation. Hydrogenolysis of 15 provided fumarofine (1), which was methylated with diazomethane to give O-methyl-fumarofine (2).

• 公益社団法人日本薬学会の論文
• 1983-06-25

著者

• 山岸 喬

  Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy

• 山岸 浩

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 安田 信吾

  金沢大・薬

• 安田 信吾

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 足森 厚之

  Research Division, The Green Cross Corporation

• 足森 厚之

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 足森 厚之

  Research Division The Green Cross Corporation

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