Ouinolone系抗菌剤の研究(第2報)7-Aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid及びその関連化合物の合成と抗菌活性

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概要

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• 7-Aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and their derivatives (8-10) were synthesized and their antibacterial activities were evaluated. Among them, compounds (10d-f, k) having an alkyl group at α-position of the amino group were found to have in vitro and in vivo antibacterial activity comparable to that of ciprofloxacin (1). Structure-activity relationship of these compounds was also stated.

• 社団法人日本薬学会の論文
• 1991-01-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 安田 信吾

  北陸製薬株式会社中央研究所研究開発本部

• 伊藤 安夫

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  北陸製薬株式会社研究開発本部

• 吉田 敏彦

  北陸製薬株式会社中央研究所

• 山本 陽一

  北陸製薬株式会社中央研究所

• 八木 典幸

  北陸製薬株式会社中央研究所

• 高橋 慶衛

  北陸製薬株式会社中央研究所

• 伊藤 安夫

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 加藤 日出男

  北陸製薬株式会社中央研究所

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