Polymorphism of α-[(tert-Butylamino) methyl]-2-chloro-4-hydroxybenzyl Alcohol Hydrochloride (HOKU-81)
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概要
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Two crystalline forms of α-[(tert-butylamino) methyl]-2-chloro-4-hydroxybenzyl alcohol hydrochloride (HOKU-81) were found by X-ray powder diffraction and infrared spectroscopic analyses. By means of differential scanning calorimetry (DSC), the melting points of forms I and II were found to be 179 and 181℃, respectively. It was found by simultaneous DSC and thermogravimetry that the two polymorphs of HOKU-81 decomposed upon further heating. Both polymorphs of HOKU-81 were very stable to humidity, heating and mechanical treatments such as grinding or compressing. These physicochemical properties of HOKU-81 are very different from those of tulobuterol hydrochloride, a pre-metabolite form of HOKU-81 in humans and an excellent bronchodilator.
- 公益社団法人日本薬学会の論文
- 1983-03-25
著者
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加藤 日出男
北陸製薬株式会社
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加藤 日出男
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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伊藤 安夫
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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伊藤 安夫
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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松村 阜子
北陸製薬株式会社中央研究所
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斎藤 勝
北陸製薬
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松村 阜子
Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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