Novel Phenoxyalkylamine Derivatives. II. : Synthesis and Ca^<2+>-Antagonistic Activities of α-Alkyl-α-[(phenoxypropylamino)propyl]-benzeneacetonitrile Derivatives
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概要
- 論文の詳細を見る
α-Alkyl-α-[(phenoxypropylamino)propyl]benzeneacetonitrile derivatives containing various substituents on the ring of the benzeneacetonitrile moiety (A), the quaternary carbon atom and the ring of the phenoxy moiety (B) were prepared, and their Ca^<2+>-antagonistic activities were evaluated. Among these compounds, the N-Me derivatives with a 3,4,5-(OMe)_3 group on the A ring, an iso-Pr group on the quaternary carbon atom, and a m-OMe, 3,5-(OMe)_2,3,5-Me_2 or 3,4,5-(OMe)_3 group on the B ring were found to possess Ca^<2+>-antagonistic activity higher than pA_2=9. The effects of substitutions at the A ring, the quaternary carbon atom and the B ring are discussed.
- 社団法人日本薬学会の論文
- 1988-01-25
著者
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加藤 日出男
北陸製薬株式会社
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岩永 裕氏
北陸製薬株式会社
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森川 宏二
北陸製薬株式会社
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桜井 俊一郎
北陸製薬株式会社中央研究所研究開発本部
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越中 栄一
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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伊藤 安夫
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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加藤 日出男
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,
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伊藤 安夫
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,
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桜井 俊一郎
Central Research Laboratory, Hokuriku Seiyaku Co., Ltd.,
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見谷 一也
Central Research Laboratory, Hokuriku Seiyaku Co., Ltd.,
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森川 宏二
Central Research Laboratory, Hokuriku Seiyaku Co., Ltd.,
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越中 栄一
Central Research Laboratory, Hokuriku Seiyaku Co., Ltd.,
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岩永 裕氏
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,
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吉田 敏彦
北陸製薬株式会社中央研究所
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岩永 裕氏
北陸製薬株式会社研究統括部薬理研究所
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吉田 敏彦
Central Research Laboratory, Hokuriku Seiyaku Co., Ltd.,
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越中 栄一
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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伊藤 安夫
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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見谷 一也
Central Research Laboratory Hokuriku Seiyaku Co. Ltd.
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加藤 日出男
北陸製薬株式会社中央研究所
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