医薬品の両性イオン化(第1報)4-(2-Chlorodibenz[b, f][1,4]oxazepin-11-yl)piaerazine, 4-(2-Chlorodibenzo[b, f][1,4]thiazepin-11-yl)-piperazine及び4-(11H-Dibenz[b, e]azepin-6-yl)piperazineのN-アルキルカルボン酸誘導体の合成とその薬理作用
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概要
- 論文の詳細を見る
The piperazine N-alkylcarboxylic acids of 2-chlorodibenz[b, f] [1,4] oxazepine (3a), 2-chlorodibenzo[b, f] [1,4] thiazerine (3b), and dipenz[b, e]azepine (3c) from the corresponding piperazines (1a-c, R^1=H) were synthesized via the piperazine N-alkylcarboxylates (2a-c). The pharmacolosical activities of the piperazine N-alkylcarboxylic acids (3a-c) were evaluated. Compared with the parent compounds (1a-c), 3a-c (n=1-5) showed weak inhibitory activities on the uptake of noradrenaline and 5-hydroxytryptamine (5-HT) into hypothalamus vesicles and moderate antagonistic actions to 5-HT_2 and H_1 in several tissues.
- 社団法人日本薬学会の論文
- 1992-07-25
著者
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澤西 啓之
北陸大学薬学部附属創薬研究施設
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加藤 日出男
北陸製薬株式会社
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大橋 徹生
北陸製薬株式会社
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伊藤 安夫
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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村松 広美
北陸大学薬学部附属創薬研究施設
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岩崎 信彦
北陸製薬株式会社研究開発本部
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垣内 正人
北陸製薬株式会社研究開発本部
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伊藤 安夫
北陸製薬株式会社研究開発本部
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岩崎 信彦
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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澤西 啓之
北陸大・薬
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澤西 啓之
The First Division Of The Research Laboratory For Development Of Medicine Hokuriku University
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澤西 啓之
北陸大学薬学部
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伊藤 安夫
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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加藤 日出男
北陸製薬株式会社中央研究所
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