Dexamethasone valerate (DV-17)と他の副腎皮質ステロイド外用剤のウサギにおける刺激性試験 : 皮膚および眼粘膜一次刺激性試験ならびに皮膚累積刺激性試験

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The skin and eye primary irritation tests, and skin cumulative irritation test were performed on male rabbits, which were topically treated with a volume of 1 g/body of 0.06% and 0.12% dexamethasone valerate (DV-17) ointments as a test drug, and 0.1% hydrocortisone butyrate (HB) and 0.12% betamethasone valerate (BMV) ointments as an active control drug in order to evaluate the topical and systemic effects. No skin and eye primary irritations except minimal skin erythema and slight conjunctival redness were seen in above four corticosteroids. Judging from the results such as skin atrophy, inhibition of body weight gains, and decreases of thymus, spleen and adrenal weights, the potency of toxicities among the four corticosteroid ointments appeared to be as follows : 0.12% DV-17, 0.12% BMV > 0.1% HB> 0.06% DV-17.
日本トキシコロジー学会の論文
1982-07-25