Co_2(CO)_8-mediated Endo Mode Cyclization of Epoxy-alcohol : Synthesis of 2-Ethynyl-3-hydroxy-2-methyltetrahydropyran and 2-Ethynyl-3-hydroxy-3-methyltetrahydropyran Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Successive treatment of 4, 5-epoxy-5-methyl-7-trimethylsilyl-6-heptyne-1-ol with Co_2(CO)_8 at 0℃ and a catalytic amount of BF_3・OEt_2 at -78℃ gave the tetrahydropyran derivatives with the cobalt-complexed moiety. Similarly 4, 5-epoxy-4-methyl-7-trimethylsilyl-6-heptyne-1-ol underwent ring closure under the above conditions to provide the corresponding tetrahydropyran derivatives. The preferential endo mode cyclization over the exo one was observed in these experiments.
- 公益社団法人日本薬学会の論文
- 2001-05-01
著者
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HANAOKA Miyoji
Faculty of Pharmaceutical Sciences, Kanazawa University
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Mukai C
Faculty Of Pharmaceutical Sciences Kanazawa University
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Mukai Chisato
Faculty Of Pharmaceutical Sciences Kanazawa University
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Hanaoka Miyoji
Faculty Of Pharmaceutical Sciences Kanazawa University
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YAMAGUCHI Sumie
Faculty of Pharmaceutical Sciences, Kanazawa University
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KIM In
Faculty of Pharmaceutical Sciences, Kanazawa University
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Yamaguchi Sumie
Faculty Of Pharmaceutical Sciences Kanazawa University
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Kim In
Faculty Of Pharmaceutical Sciences Kanazawa University
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