Inhibitory Effects of Eleutherococcus senticosus Extracts on Amyloid β(25-35)-Induced Neuritic Atrophy and Synaptic Loss
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概要
- 論文の詳細を見る
Neurons with atrophic neurites may remain alive and therefore may have the potential to regenerate even when neuronal death has occurred in some parts of the brain. This study aimed to explore effects of drugs that can facilitate the regeneration of neurites and the reconstruction of synapses even in severely damaged neurons. We investigated the effects of Eleutherococcus senticosus extracts on the regeneration of neurites and the reconstruction of synapses in rat cultured cortical neurons damaged by amyloid β (Aβ)(25-35). Treatment with Aβ(25-35) (10 μM) induced axonal and dendritic atrophies and synaptic loss in cortical neurons. Subsequent treatment with the methanol extract and the water extract of E. senticosus (10 – 1000 ng/ml) resulted in significant axonal and dendritic regenerations and reconstruction of neuronal synapses. Co-application of the extract and Aβ(25-35) attenuated Aβ(25-35)-induced neuronal death. We investigated neurite outgrowth activities of eleutherosides B and E and isoflaxidin, which are known as major compounds in E. senticosus. Although eleutheroside B protected against Aβ(25-35)-induced dendritic and axonal atrophies, the activities of eleutheroside E and isofraxidin were less than that of eleutheroside B. Although the contents of these three compounds in the water extract were less than in the methanol extract, restoring activities against neuronal damages were not different between the two extracts. In conclusion, extracts of E. senticosus protect against neuritic atrophy and cell death under Aβ treatment, and one of active constituents may be eleutheroside B.
- 社団法人 日本薬理学会の論文
- 2008-07-20
著者
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Shu Zhu
富山大学和漢医薬学総合研究所生薬資源科学分野
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Zhu Shu
中華人民共和国
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Zhu Shu
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine University
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Tanaka Ken
Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, Univers
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Komatsu Katsuko
Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, Univers
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Zhu Shu
Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama
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TOHDA Chihiro
Division of Biofunctional Evaluation, Research Center for Ethnomedicine, University of Toyama
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ICHIMURA Mahoko
Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama
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BAI Yanjing
Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama
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Zhu Shu
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Zhu Shu
Division Of Pharmacognosy Department Of Medicinal Resources Istitute Of Natural Medicine University
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Komatsu Katsuko
富山大学和漢医薬学総合研究所
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Komatsu K
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Komatsu K
Institute Of Natural Medical Toyama Medicine And Pharmaceutical University
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med
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Komatsu Katsuko
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Komatsu Katsuko
Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama
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Komatsu K
Institute Of Natural Medicine University Of Toyama
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Komatsu Katsuko
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Istitute Of Natural Medicine University
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Tanaka Ken
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Bai Yanjing
Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama
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Tohda C
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Tohda Chihiro
富山大学和漢医薬学総合研究所 民族薬物研究センター 薬効解析部
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Tohda Chihiro
Division Of Biofunctional Evaluation Research Center For Ethnomedicine Institute Of Natural Medicine
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Tohda Chihiro
Division Of Biofunctional Evaluation Research Center For Ethnomedicine University Of Toyama
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Ichimura Mahoko
Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama
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Tanaka Ken
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine University
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Zhu Shu
Division of Parmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
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Komatsu Katsuko
Division of Parmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
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