Comparison of histamine release induced by synthetic polycations with that by compound 48/80 from rat mast cells.
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概要
- 論文の詳細を見る
We compared the histamine release induced by polyethylenimines and polyallylamines with that induced by compound 48/80. Lidocaine inhibited the histamine release induced by polyethylenimine with a molecular weight of 600 (PEI<SUB>6</SUB>), but disodium cromoglycate did not. The histamine releases induced by all polyethylenimines and polyallylamines tested were inhibited by lidocaine, but not by disodium cromoglycate. islet activating protein inhibited the histamine release induced by PEI<SUB>6</SUB>. Its effects on the release by other polyethylenimines and polyallylamines were less than that on PEI<SUB>6</SUB>. It is likely that the inhibition of G proteins by islet activating protein resulted in a decrease of the histamine release. This possibility was supported by the finding that guanyl-5'-(β, γ-imino) triphosphate enhanced the histamine release. An inhibitor of polyphosphoinositide phosphodiesterase, neomycin, did not affect the histamine releases induced by these polymers. The effect of PEI<SUB>6</SUB> seemed to resemble that of compound 48/80. After pretreatment of mast cells with wheat germ agglutinin and with <I>Limax flavus</I> agglutinin, releases of histamine induced by PEI6 and compound 48/80 decreased, suggesting that the binding sites of PEI<SUB>6</SUB> and compound 48/80 had sialic acid and/ or N-acetyl glucosamine residues. The binding site for PEI<SUB>6</SUB> seemed to especially overlap those of compound 48/80.
- 公益社団法人 日本薬理学会の論文
著者
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Yoshino Yasushi
Department Of Applied Pharmacology School Of Pharmacy Hoshi University:research Institute Of Nippon
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UCHIDA Masaatsu
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SEKINO Hidehito
Department of Molecular Pharmacology, Meiji College of Pharmacy
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NAGAYA Kohi
Department of Molecular Pharmacology, Meiji College of Pharmacy
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SUZUKI-NISHIMURA Tamiko
Department of Molecular Pharmacology, Meiji College of Pharmacy
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