Inhibitory Effects of Sialic Acid- or N-Acetylglucosamine-Specific Lectins on Histamine Release Induced by Compound 48/80, Bradykinin and a Polyethylenimine in Rat Peritoneal Mast Cells.
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概要
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The effects of seven lectins with various sugar-specificities on histamine release from rat peritoneal mast cells induced by non-immunologic stimuli were studied. The non-immunologic stimuli used were three basic secretagogues, compound 48/80, bradykinin and PEI<SUB>6</SUB> (polyethylenimine with a molecular weight of 600). In this study, we observed inhibition of the histamine release by <I>Macckia amurensis</I> mitogen and <I>Solanum tuberosum</I> agglutinin (100 μg/ml at 371C for 10 min), which are specific for sialic acid-α2, 3-<I>N</I>-acetyl galactosamine (Siaα2, 3Ga1NAc) and <I>N</I>-acetyl glucosamine (G1cNAc) oligomers, respectively. The effects of <I>Phytolacca americana</I> mitogen and <I>Sambucus sieboldiana</I> agglutinin were different. Three lectins specific for mucin type oligosaccharides inhibited the histamine release induced by compound 48/80 but not that induced by bradykinin or PEI<SUB>6</SUB>. Since bradykinin and PEI<SUB>6</SUB> additively enhanced the histamine release induced by compound 48/80, they partially shared the same signalling pathways. Glycoproteins with bisecting GlcNAc and Sia residues, as described previously (Jpn. J. Pharmacol. 57, 79-90, 1991), seemed to be one of the action sites for compound 48/80, bradykinin and PEI<SUB>6</SUB>. In addition to the direct activation of the pertussis toxin-sensitive G proteins, we propose another mechanism of non-immunologic stimuli via specific glycoproteins on rat peritoneal mast cells. The apparent sugar residues involved were asparagine-linked oligosaccharides with Sia (especially Siaα2, 3Gal), GlcNAc oligomers and/or bisecting GlcNAc.
- 公益社団法人 日本薬理学会の論文
著者
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Matsuda Koji
Department Of Endoscopy Jikei University
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UCHIDA Masaatsu
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SUZUKI-NISHIMURA Tamiko
Department of Molecular Pharmacology, Meiji College of Pharmacy
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Suzuki-Nishimura Tamiko
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo 154, Japan
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Niitsuma Akinao
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo 154, Japan
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Uchida Masaatsu
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo 154, Japan
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