Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Delayed Rectifier K^+ Current in Guinea Pig Atrial Myocytes
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概要
- 論文の詳細を見る
Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K<SUP>+</SUP> current (I<SUB>K</SUB>) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolarization and tail currents (I<SUB>K-tail</SUB>) at −40 mV. The concentration of sematilide required for a 50% decrease in I<SUB>K-tail</SUB> was approximately 50 μM. The sematilidesensitive current obtained using a triangular voltage command exhibited marked inward rectification and had the maximum amplitude at −30 mV. These results suggest that sematilide inhibits rapidly activating I<SUB>K</SUB> in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.
- 社団法人 日本薬理学会の論文
- 1996-08-01
著者
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村木 克彦
名古屋市大・院・細胞分子薬効解析
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Kurihara Atsushi
Biology Section Shirakawa Laboratory Nippon Roussel Co. Ltd.
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Muraki Katsuhiko
Department Of Cellular Pharmacology School Of Pharmacy Aichi-gakuin University
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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ISHII Yasunori
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe M
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City Uni
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