Relationships Between the First Ovulation Postpartum and Polymorphism in Genes Relating to Function of Immunity, Metabolism and Reproduction in High-producing Dairy Cows

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概要

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• The decrease in fertility and conception rates of high-producing dairy cows is one of the major negative impacts for todays producers. The recovery of ovarian activity postpartum is affected by the status of immunity, metabolism and reproduction and plays a critical role in subsequent fertility after parturition in the cow. In the present study we investigated the relationships between polymorphisms in genes relating to the above functions and the first postpartum ovulation as a marker of the recovery of ovarian function in the cow. In immune function related-factors, the occurrence of first postpartum ovulation within 3 weeks in the C/C genotypes of tumor necrosis factor α (TNFα) exon (55.4%) and the A/G genotypes of TNFα promoter (55.4%) was significantly higher than that in T/T genotypes of TNF α exon (14.3%) and A/A genotypes of TNFα promoter (14.3%). Moreover, anovulatory cows with the T/T genotype of TNFα exon and the A/A genotype of TNFα promoter tended to have a prolonged days open compared with those of the other genotypes of TNFα polymorphisms. In metabolic function-related factors, ovulatory and anovulatory cows had a different distribution for alleles of the growth hormone receptor, but there were no significant differences in genotype and allele frequency of insulin-like growth factor-I polymorphism. No significant relationships were found between ovarian function after parturition and SNPs for reproduction-related genes. In conclusion, polymorphisms of TNFα gene both in exon and promoter regions have a strong association with the early first ovulation within 3 weeks after parturition in the high-producing dairy cow. Taken together, polymorphisms of TNFα gene could be strongly related to early first ovulation after parturition, thus being an effective tool of selection for improving reproductive performance in the high-producing dairy cow.

• 日本繁殖生物学会の論文
• 2011-02-01

著者

• 宮本 明夫

  帯広畜産大学畜産学部

• Miyamoto Akio

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture & Veterinary Medicine

• SHIRASUNA Koumei

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• MATSUI Motozumi

  Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medic

• Sasahara Kiemi

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Sasahara Kiemi

  帯広畜産大学 大学院畜産衛生学

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大

• Masuda Yutaka

  Department of Agricultural Chemistry, The University of Tokyo

• Shimizu Takashi

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• KAWASHIMA Chiho

  Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Med

• KIDA Katsuya

  Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Med

• Kida Katsuya

  Field Center Of Animal Science And Agriculture Obihiro University Of Agriculture And Veterinary Medi

• Matsui Motozumi

  Lab. Of Theriogenology Dep. Of Applied Veterinary Medicine Obihiro Univ. Of Agriculture And Veterina

• Kawashima Chiho

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Shirasuna Koumei

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Shirasuna Koumei

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Amaya Montoya

  帯広畜産大学 畜産学研究科畜産衛生学

• Kawashima Chiho

  Field Center Of Animal Science And Agriculture Obihiro University Of Agriculture And Veterinary Medi

• Matsui Motozumi

  Department Of Clinically Veterinary Sciences Obihiro University Of Agriculture And Veterinary Medici

• 清水 隆

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 松井 基純

  The United Graduate School Of Veterinary Sciences Gifu University

• 宮本 明夫

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大学・畜産科学科

• Suzuki Takahiro

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• MURAYAMA Chiaki

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• AOKI Yuka

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• Aoki Yuka

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Masuda Yutaka

  Department Of Food Production Science Obihiro University Of Agriculture And Veterinary Medicine

• Murayama Chiaki

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Masuda Yutaka

  Deparmtent Of Cardiovascular Surgery Institute Of Health Biosciences University Of Tokushima Graduat

• Kawashima Chiho

  Field Center Of Animal Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine Hokkaido 080-8555 J

• Matsui Motozumi

  Department Of Clinical Veterinary Science Obihiro University Of Agriculture And Veterinary Medicine

• MATSUI Motozumi

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

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