発情周期中およびプロスタグランジンF2α投与後のウシ黄体内でのアンジオポエチンと受容体TieのmRNA発現の変化:黄体退行開始機構への関与の可能性
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概要
- 論文の詳細を見る
Local angiogenesis and angiolysis in the corpus luteum (CL) relate to the luteal function. Recent studies indicate that angiopoietins (ANPT) and their receptors Tie regulate remodeling of microvasculature. We therefore examined 1) the relative changes in the expression of mRNA for ANPT-1, ANPT-2, Tie1 and Tie2 in bovine CL by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) during the estrous cycle and prostaglandin F2α (PGF2α)-induced luteolysis, and 2) the effect of ANPT-2 on progesterone (P4) release from CL at the late stage of the estrous cycle by an in vitro microdialysis system (MDS). The CLs were classified into 4 stages (early: Day 2-5, n=7, mid: Day 8-12, n=15, late: Day 15-17, n=9, regressing: Day >18, n=19). The levels of ANPT-1 mRNA in early and regressing CL were lower than those in mid and late CL, whereas ANPT-2 mRNA expression did not change during the estrous cycle. The Tie2 mRNA expression decreased as the CL aged. During PGF2α-induced luteolysis, ANPT-2 mRNA expression was acutely and temporally increased at 2 h after PGF2α injection. The expression of ANPT-1 mRNA was decreased from 4 h after PGF2α injection and kept low levels. In the experiment with the in vitro MDS, an infusion of ANPT-2 (100 ng/ml) acutely inhibited P4 release from late CL. Overall, results suggest that decrease of ANPT-1 mRNA is a basic mechanism of vascular remodeling in CL. In addition, ANPT-2 might play a role in regulation of P4 secretion in CL during luteolysis.
- 日本繁殖生物学会の論文
著者
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MATSUI Motozumi
Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medic
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MIYAMOTO Akio
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
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Acosta Tomas
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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BERISHA Bajram
Institute of Physiology, Technical University of Munich
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SCHAMS Dieter
Institute of Physiology, Technical University of Munich
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KOBAYASHI Shuichi
Department of Surgery III, Nara Medical University
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田中 純
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
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TETSUKA Masa
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
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