Angiogenic Factors (VEGF,FGF and IGF) in the Bovine Corpus Luteum
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概要
- 論文の詳細を見る
Angiogenesis, the development of the new capillaries by endothelial cell proliferation and outgrowth from pre-existing vessels, is one of the prominent features of early corpus luteum (CL). The process of angiogenesis is an important component of normal development and function of CL. Of the numerous promoters of angiogenesis and maintenance of new established capillaries that have been identified, the most important factors appear to be vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF). The biological effects of VEGF and FGF factor families are mediated by signaling through specific tyrosine kinase receptors. The VEGF, FGF and IGF family members in bovine CL are discussed with the literature available for large domestic animals. The highest expression for VEGF, VEGFR-2, FGF-2, FGFR, IGF-1, IGF-2 and IGFR1 were found during the early luteal phase (Ld 1-4) followed by a significant decrease afterwards. The VEGF and IGF-1 protein was localized predominantly in luteal cells. FGF-1 mRNA expression peaked (P<0.05) during mid-luteal stage and FGF-1 protein was localized in cytoplasm of luteal cells, but endothelial cells are always negative. FGF-2 protein during angiogenesis (d 1-5) was found in cytoplasm of endothelial cells and changed thereafter exclusively to the cytoplasm of luteal cells. In contrast, the IGF-2 protein is exclusively localized in pericytes and few endothelial cells. The results obtained (mainly in ruminant) suggest an important role of these growth factors for angiogenesis and furthermore for maintenance and function of the bovine corpus luteum.
- 日本繁殖生物学会の論文
- 2002-06-01
著者
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Schams D
Technical Univ. Munich Freising‐weihenstphan Deu
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Berisha B
Technical Univ. Munich Freising‐weihenstphan Deu
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BERISHA Bajram
Institute of Physiology, Technical University of Munich
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SCHAMS Dieter
Institute of Physiology, Technical University of Munich
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Schams Dieter
帯広畜産大学 畜産科学科・生殖科学研究室
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Schams Dieter
Institut Fur Physiologie Forschungszentrum Fur Milch Und Lebensmittel Weihenstephan Technische Unive
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SCHAMS Dieter
Institut für Physiologie, Süddeutsche Versuchs- und Forschungsanstalt für Milchwirtschaft, Technische Universität München
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BERISHA Bajram
Institute of Physiology Weihenstephan, Technical University of Munich
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