Effect of Intraluteal Injection of Endothelin Type A Receptor Antagonist on PGF_<2α>-induced Luteolysis in the Cow

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概要

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• Endothelin-1 (ET-1) is a luteolytic mediator in the bovine corpus luteum (CL), and its action appears to be via endothelin type A receptor (ETR-A). Thus, the aim of the present study was to determine the effect of ETR-A antagonist on PGF2α-induced luteolysis in the cow. Cows on days 10-12 of the estrous cycle were subjected to five intraluteal injections of the ETR-A antagonist LU 135252 in saline or only saline at -0.5, 2, 4, 6, and 8 h after PGF2α administration (=0 h). Serial luteal biopsies were conducted to determine the expression of mRNA in the luteal tissue. There were no significant differences in the decrease in plasma progesterone (P) concentrations and the mRNA expressions of steroidogenic acute regulatory protein and 3 β-hydroxysteroid dehydrogenase/Δ5, Δ4-isomerase between the ETR-A antagonist-treated group and the control group. However, the start of the decline in CL volume and blood flow area surrounding the CL was delayed for almost two days in the ETR-A antagonist-treated group compared to the control group. The mRNA expression of preproET-1 and endothelin type B receptor increased in both groups, while the ETR-A mRNA remained unchanged. In addition, caspase-3 mRNA expression increased significantly at 24 h in the control group only and its level was higher than that of the ETR-A antagonist-treated group. Thus, the present study suggests that ET-1 regulates structural luteolysis via ETR-A by controlling blood vessel contraction in the CL of the cow.

• 日本繁殖生物学会の論文
• 2006-08-01

著者

• 宮本 明夫

  帯広畜産大学畜産学部

• Miyamoto Akio

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture & Veterinary Medicine

• SHIRASUNA Koumei

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• MATSUI Motozumi

  Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medic

• Sasahara Kiemi

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Sasahara Kiemi

  帯広畜産大学 大学院畜産衛生学

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大

• Schams D

  Technical Univ. Munich Freising‐weihenstphan Deu

• Berisha B

  Technical Univ. Munich Freising‐weihenstphan Deu

• BERISHA Bajram

  Institute of Physiology, Technical University of Munich

• SCHAMS Dieter

  Institute of Physiology, Technical University of Munich

• Matsui Motozumi

  Lab. Of Theriogenology Dep. Of Applied Veterinary Medicine Obihiro Univ. Of Agriculture And Veterina

• Shirasuna Koumei

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Shirasuna Koumei

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Schams Dieter

  帯広畜産大学 畜産科学科・生殖科学研究室

• WATANABE Sho

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• YAMAMOTO Dai

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• Watanabe Sho

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Amaya Montoya

  帯広畜産大学 畜産学研究科畜産衛生学

• Matsui Motozumi

  Department Of Clinically Veterinary Sciences Obihiro University Of Agriculture And Veterinary Medici

• Yamamoto Dai

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 松井 基純

  The United Graduate School Of Veterinary Sciences Gifu University

• 宮本 明夫

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Schams Dieter

  Institut Fur Physiologie Forschungszentrum Fur Milch Und Lebensmittel Weihenstephan Technische Unive

• 宮本 明夫

  帯広畜産大学・畜産科学科

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Matsui Motozumi

  Department Of Clinical Veterinary Science Obihiro University Of Agriculture And Veterinary Medicine

• SCHAMS Dieter

  Institut für Physiologie, Süddeutsche Versuchs- und Forschungsanstalt für Milchwirtschaft, Technische Universität München

• MATSUI Motozumi

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

• BERISHA Bajram

  Institute of Physiology Weihenstephan, Technical University of Munich

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