Expression of mRNA for Cell Adhesion Molecules in the Bovine Corpus Luteum During the Estrous Cycle and PGF_<2α>-Induced Luteolysis
スポンサーリンク
概要
- 論文の詳細を見る
Cell-to-cell interaction via cell contact-dependent pathway is essentially important for maintenance and regulation of corpus luteum (CL) integrity and its physiological actions. The objective of the present study was to evaluate the mRNA expression of the cell adhesion molecules (CAMs) that are constituent factors of gap junctions [connexin (Cx) 43] and adherence junctions (VE-, E-, N-cadherin) in two types of endothelial cells from the mid CL and in CL tissue during the estrous cycle and PGF2α-induced luteolysis in the cow. Specific mRNA expression for Cx43 and N-cadherin was detected in cytokeratin-positive (CK+) and cytokeratin-negative (CK-) luteal endothelial cells (EC) and fully luteinized granulosa cells (LGC). E-cadherin mRNA was expressed in CK+EC and LGC, but not in CK-EC. VE-cadherin mRNA was expressed in both CK+ and CK-EC. During the estrous cycle, Cx43 mRNA expression was significantly lower in the regressing CL. VE-cadherin expression also tended to increase in the mid CL and increased significantly in the regressing CL. E-cadherin mRNA expression was higher in the early and late CL than in the mid-and regressing CL. N-cadherin mRNA expression gradually increased from the early to late CL followed by a decrease in the regressing CL. During PGF2α-induced luteolysis, Cx43 mRNA expression appeared to increase, and VE-cadherin and E-cadherin mRNA significantly increased at 24 h. N-cadherin mRNA expression decreased 2 and 4 h after PGF2α administration. Collectively, expression of the mRNAs for CAMs was different in the two types of luteal endothelial cells and fully luteinized granulosa cells and changed independently in the CL during the estrous cycle and PGF2α-induced luteolysis in the cow. The results suggest that CAMs play physiological roles in cell-to-cell communication to regulate both gap and adherence junctions during CL development and regression in the cow.
- 日本繁殖生物学会の論文
- 2007-12-01
著者
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宮本 明夫
帯広畜産大学畜産学部
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Miyamoto Akio
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture & Veterinary Medicine
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SHIRASUNA Koumei
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin
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SASAHARA Kiemi
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin
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Sasahara Kiemi
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Sasahara Kiemi
帯広畜産大学 大学院畜産衛生学
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Miyamoto Akio
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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宮本 明夫
帯広畜産大
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Shimizu Takashi
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Shirasuna Koumei
Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine
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Shirasuna Koumei
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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WATANABE Sho
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin
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Watanabe Sho
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Amaya Montoya
帯広畜産大学 畜産学研究科畜産衛生学
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NAGAI Kaya
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin
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RICKEN Albert
Institute of Anatomy, University of Leipzig
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SPANEL-BOROWSKI Katharina
Institute of Anatomy, University of Leipzig
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Spanel-borowski Katharina
Institute Of Anatomy University Of Leipzig
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清水 隆
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Nagai Kaya
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Ricken Albert
Institute Of Anatomy University Of Leipzig
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宮本 明夫
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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宮本 明夫
帯広畜産大学・畜産科学科
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Miyamoto Akio
Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine
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