Changes in the Messenger RNA Expressions of the Endothelin-1 and Angiotensin Systems in Mature Follicles of the Superovulated Bovine Ovary
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概要
- 論文の詳細を見る
The aim of the present study was to examine the messenger RNA expressions of the endothelin and angiotensin systems during the periovulatory phase in gonadotrophin releasing hormone (GnRH)-treated cows. Ovaries were collected by transvaginal ovariectomy (n=5 cows/group), and the follicles (n=5, one follicle/cow) were classified into the following groups: before GnRH administration (control, before LH surge), 3-5 h after GnRH (during LH surge), 10 h after GnRH; 20 h after GnRH, 25 h after GnRH (peri-ovulation), and early CL (Days 2-3). Expression of mRNA was investigated using quantitative real-time PCR (Rotor-Gene 3000). The expression of angiotensin converting enzyme (ACE) mRNA significantly decreased immediately after onset of the LH surge and remained at low levels. The levels of angiotensin II receptor type 1 (AT1R) and type 2 (AT2R) expression during the periovulatory period significantly decreased compared with other periods. The concentration of angiotensin II in follicular fluid began to increase 10 h after GnRH treatment and further increased as ovulation approached. The level of ET-1 mRNA significantly decreased 10 h after GnRH treatment compared with the levels before GnRH treatment and those of the early CL period. The expression of ETR-A and ETR-B mRNA during the periovulatory period were lower than in other periods. The expression of ECE-1 mRNA began to decrease in the LH surge period and significantly decrease in the periovulatory period compared with other periods. These results suggest that the vasoactive peptides angiotensin and endothelin may be associated with final maturation of follicles.
- 日本繁殖生物学会の論文
著者
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Miyamoto Akio
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture & Veterinary Medicine
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Miyamoto Akio
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Schams D
Technical Univ. Munich Freising‐weihenstphan Deu
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Berisha B
Technical Univ. Munich Freising‐weihenstphan Deu
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Shimizu Takashi
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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BERISHA Bajram
Institute of Physiology, Technical University of Munich
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SCHAMS Dieter
Institute of Physiology, Technical University of Munich
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Schams Dieter
帯広畜産大学 畜産科学科・生殖科学研究室
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清水 隆
Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Schams Dieter
Institut Fur Physiologie Forschungszentrum Fur Milch Und Lebensmittel Weihenstephan Technische Unive
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Miyamoto Akio
Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine
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SCHAMS Dieter
Institut für Physiologie, Süddeutsche Versuchs- und Forschungsanstalt für Milchwirtschaft, Technische Universität München
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BERISHA Bajram
Institute of Physiology Weihenstephan, Technical University of Munich
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