Induction of Ovulation with GnRH and PGF_<2α> at Two Different Stages During the Early Postpartum Period in Dairy Cows : Ovarian Response and Changes in Hormone Concentrations

スポンサーリンク

概要

• 論文の詳細を見る

• The aims of this study were 1) to determine whether dairy cows can be induced to ovulate by the treatment with GnRH followed by PGF2α during the early postpartum period and 2) to describe their ovarian and hormonal responses according to ovarian status. Cows were divided in two groups and received 10 μg of buserelin followed by 500 μg of cloprostenol 7 days apart starting from 21 (GnRH21, n=7) or around 37 days postpartum (GnRH37, n=7). The groups were further classified according to presence (-CL) or absence (-NCL) of functional corpora lutea (CL) on the day of GnRH treatment (d 0): GnRH21-NCL (n=4), GnRH21-CL (n=3) and GnRH37-CL (n=7). Ovarian morphology was monitored and the concentrations of P4, E2, FSH and insulin-like growth factor 1 (IGF-1) were measured. All cows ovulated after administration of GnRH. The P4 levels of the GnRH21-NCL group from d 0 to d 5 were lower than those of the GnRH21-CL (P<0.05) and GnRH37-CL groups (P<0.01). In contrast, the E2 levels of the GnRH21-NCL group within d 2 to d 6 were higher (P<0.05) than those of the other groups. Compared with the GnRH37-CL group, the GnRH21-NCL group had more small follicles on d 2 (P<0.05), d 3 (P<0.01) and d 4 (P<0.01) and more large follicles on d 5 (P<0.05). The induced CL and new ovulatory follicles were larger in the GnRH21-NCL group compared with the GnRH21-CL (P<0.001 and P<0.01) and GnRH37-CL groups (P<0.001 and P<0.05). IGF-1 did not differ among the groups. The GnRH21-NCL group had higher FSH levels than the GnRH21-CL (P<0.01) and GnRH37-CL groups (P<0.001) on d 0. Low P4 and high FSH levels may suggest higher gonadotropin support on the enhanced ovarian morphology of the GnRH21-NCL group. PGF2α treatment induced CL regression and subsequent ovulation in 3/4 (75%), 3/3 (100%) and 7/7 (100%) cows in the GnRH21-NCL, GnRH21-CL and GnRH37-CL groups, respectively. In conclusion, a 7-day GnRH-PGF2α synchronization protocol can effectively induce dairy cows to ovulate as early as 21 days postpartum, regardless of ovarian status.

• 日本繁殖生物学会の論文
• 2007-08-01

著者

• 宮本 明夫

  帯広畜産大学畜産学部

• Miyamoto Akio

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture & Veterinary Medicine

• MATSUI Motozumi

  Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medic

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大

• MIYAKE Yoh-Ichi

  Department of Veterinary Medicine, Obihiro University

• KIDA Katsuya

  Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Med

• Kawashima Chiho

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• Kida Katsuya

  Field Center Of Animal Science And Agriculture Obihiro University Of Agriculture And Veterinary Medi

• Matsui Motozumi

  Lab. Of Theriogenology Dep. Of Applied Veterinary Medicine Obihiro Univ. Of Agriculture And Veterina

• Kawashima Chiho

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• MIYAKE Yoh-Ichi

  Obihiro University of Agriculture and Veterinary Medicine

• HAYASHI Ken-Go

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• KANEKO Etsushi

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• 三宅 陽一

  岩手大学 農学部家畜繁殖学研究室

• Miyake Yoh‐ichi

  Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido

• Miyake Y

  Laboratory Of Theriogenology Faculty Of Agriculture Iwate University

• Amaya Montoya

  帯広畜産大学 畜産学研究科畜産衛生学

• AMAYA-MONTOYA Carlos

  Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu U

• MATSUDA Go

  Laboratory of Theriogenology, Department of Clinical Veterinary Science, Obihiro University of Agric

• Matsuda Go

  Laboratory Of Theriogenology Department Of Clinical Veterinary Science Obihiro University Of Agricul

• Matsui Motozumi

  Department Of Clinically Veterinary Sciences Obihiro University Of Agriculture And Veterinary Medici

• Hirabayashi Keiji

  Department Of Animal Production Ikuta Campus Meiji University

• Kaneko Etsushi

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Miyake Y

  Iwate Univ. Morioka Jpn

• 松井 基純

  The United Graduate School Of Veterinary Sciences Gifu University

• 宮本 明夫

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大学・畜産科学科

• Miyamoto A

  Laboratory Of Animal Genetics And Reproduction Obihiro University Of Agriculture And Veterinary Medi

• Hayashi Ken‐go

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Miyake Yoh-ichi

  Department Of Veterinary Medicine Obihiro University

• Miyamoto Akio

  Laboratory Of Animal Genetics And Reproduction Obihiro University Of Agriculture And Veterinary Medi

• Matsui Motozumi

  Department Of Clinical Veterinary Science Obihiro University Of Agriculture And Veterinary Medicine

• MATSUI Motozumi

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

• MIYAKE Yoh-Ichi

  Department of Applied Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

関連論文

• Gene Expression of 11β-HSD and Glucocorticoid Receptor in the Bovine (Bos taurus) Follicle During Follicular Maturation and Atresia: The Role of Follicular Stimulating Hormone
• Classification of Bovine Follicles Based on the Concentrations of Steroids, Glucose and Lactate in Follicular Fluid and the Status of Accompanying Follicles
• Vascular Changes in the Corpus Luteum During Early Pregnancy in the Cow
• Effects of Scrotal Insulation and Pathological Lesions on α-Smooth Muscle Actin (SMA) and Vimentin in the Bull Testes
• ウシ優性卵胞と閉鎖卵胞の卵胞液中におけるN-アセチルグルコサミニルトランスフェラーゼI活性の解析
• Prostaglandin F_ Differentially Affects mRNA Expression Relating to Angiogenesis, Vasoactivation and Prostaglandins in the Early and Mid Corpus Luteum in the Cow
• ウシ成熟卵胞内におけるGnRH投与による排卵時期の Fibroblast Growth Factor 1 (FGF1) およびFGF7遺伝子発現の変化
• eCG/hCG処理した未成熟雌マウスの卵巣におけるPin1(ペプチジルプロピルイソメラーゼ)の発現
• 非繁殖季節のめん羊における異なる3種の発情・排卵誘起法の比較
• Basal Levels and GnRH-induced Responses of Peripheral Testosterone and Estrogen in Holstein Bulls with Poor Semen Quality
• ニホンジカ (Cervus nippon) 成熟雄における血清LHおよびテストステロン濃度の周年変化
• ウシ生体を用いた黄体形成期における黄体内のプロスタグランジン(PG)F2αおよびPGE2濃度の経時的変化
• MDSを用いた馬主席卵胞のLHとPGF_感作試験(臨床繁殖学)
• 雌仔ウシおよび成熟雌ウシの末梢血中プロジェステロンとエンドセリン濃度の変化 : PGF_投与の影響
• 磁気誘導薬剤配送システムを用いた磁性薬剤の血管内集積に関する研究
• ウシ主席卵胞のLHサージへの暴露は黄体形成に不可欠である
• Angiotensin II Secretion by the Bovine Oviduct is Stimulated by Luteinizing Hormone and Ovarian Steroids
• 生後発育に伴うウシ精巣のα-SMAおよび vimentin の免疫組織化学的局在
• Distribution of Arteriolovenous Vessels, Capillaries and eNOS Expression in the Bovine Corpus Luteum During the Estrous Cycle : a Possible Implication of Different Sensitivity by Luteal Phase to PGF_ in the Increase of Luteal Blood Flow
• A novel concept for the bovine luteolytic cascade with a focus on luteal blood flow and vasoactive factors
• Effect of Suckling on the Reproductive Performance and Metabolic Status of Obese Japanese Black Cattle during the Early Postpartum Period
• Local mechanisms for luteolysis in the cow : Novel roles of vasoactive substances in the luteolytic cascade within the corpus luteum
• Metabolic Profiles in Ovulatory and Anovulatory Primiparous Dairy Cows during the First Follicular Wave Postpartum
• 性成熟時および性成熟後のホルスタイン種雄牛における月齢,体重,精巣周囲長,精液性状および血中テストステロンとエストラジオール-17β濃度の関連性(臨床繁殖学)
• CHROMOSOMAL ANALYSIS AND BLOOD TYPE EXAMINATION OF MULTIPLE BIRTHS IN EQUINE
• Genital Blood Flow and Endometrial Gene Expression During the Preovulatory Period after Prostaglandin F_-Induced Luteolysis in Different Luteal Phases in Cows
• Changes in the Messenger RNA Expressions of the Endothelin-1 and Angiotensin Systems in Mature Follicles of the Superovulated Bovine Ovary
• Colour Doppler Sonography of Cystic Ovarian Follicles in Cows
• Effect of Intraluteal Injection of Endothelin Type A Receptor Antagonist on PGF_-induced Luteolysis in the Cow
• 卵胞成長の最終的な時期のウシ卵胞内のアンギオテンシンおよびエンドセリン・システム要因のmRNA発現
• Comparative Activities of Growth Hormone and Luteinizing Hormone in the Direct Stimulation of Local Release of Progesterone from Microdialyzed Ovine Corpora Lutea In Vivo
• Effective Oxytocin Treatment on Placental Expulsion after Foaling in Heavy Draft Mares(Theriogenology)
• Relationship between Peripartal Plasma Oxytocin and Prostaglandin F_ Metabolite and Placental Expulsion Time in Heavy Draft Mares
• A Potential Use of Color Ultrasound as a Tool for Reproductive Management : New Observations Using Color Ultrasound Scanning that were not Possible with Imaging Only in Black and White
• Quantitative Evaluation of Hip Joint Laxity in 22 Border Collies Using Computed Tomography(Surgery)
• 発情周期中およびプロスタグランジンF2α投与後のウシ黄体内でのアンジオポエチンと受容体TieのmRNA発現の変化:黄体退行開始機構への関与の可能性
• Relationship between the First Ovulation within Three Weeks Postpartum and Subsequent Ovarian Cycles and Fertility in High Producing Dairy Cows
• Subjecting Holstein Heifers to Stress During the Follicular Phase Following Superovulatory Treatment May Increase the Female Sex Ratio of Embryos
• Immunoreactive Insulin-Like Growth Factor in Plasma during Pre- and Post-Partum Periods of Thoroughbred Mares from which the Newborn were Removed : its Pattern, Physiological Function and Relation to Other Hormones
• Prostaglandin F2α Differentially Affects mRNA Expression Relating to Angiogenesis, Vasoactivation and Prostaglandins in the Early and Mid Corpus Luteum in the Cow
• Expression of mRNA for Cell Adhesion Molecules in the Bovine Corpus Luteum During the Estrous Cycle and PGF_-Induced Luteolysis
• ウシ胎子卵巣における前胞状卵胞の発育と血中ホルモン濃度の動態
• Induction of Ovulation with GnRH and PGF_ at Two Different Stages During the Early Postpartum Period in Dairy Cows : Ovarian Response and Changes in Hormone Concentrations
• 生後性成熟過程のウシ潜在精巣におけるα-SMAおよび vimentin の免疫組織化学的局在パターンの異常
• ウシにおいて排卵前の卵胞内でコルチゾールの局所産生が増加する生体内での証拠
• 乳牛の第1卵胞波における卵胞への血流の変化
• ウシ卵胞発育中の顆粒層細胞におけるアンジオポエチン-Tie系のmRNA発現
• Induction of Estrus and Promotion of Fertility by Prostaglandin F_2a Administration in Mares
• ウシ卵管上皮細胞が分泌する可溶型N-アセチルグルコサミニルトランスフェラーゼ1:LH,VEGFおよびTNFαによる分泌刺激効果
• 不妊発情周期における周期回帰のメカニズム
• 体外受精および活性化処理されたウシ卵細胞質内カルシウムイオンの動態
• ウシ黄体の形成と退行 : 古くて新しい血管と黄体機能の関係
• A Simple Superovulation Method of A Single Injection of Follicle- Stimulating Hormone Combined with Equine Chorionic Gonadotropin for Superovulation of Suffolk Ewes During the Breeding Season: I. Effects of Different Treatments on the Endocrine Profiles
• 1999年度島村賞受賞講演論文 Paracrine/autocrine機構による反芻家畜の卵胞・黄体機能調節に関する研究
• Intraluteal Release of Progesterone and Prostaglandins during PGF2α-Induced Luteolysis in Ewes: Local Effects of Tumor Necrosis Factor-α
• Inflammatory Reaction in the Herniated Degenerative Disc Materials in Miniature Dachshunds
• CYTOGENETICAL STUDIES ON SWINE INTERSEXES
• Differential Effect of Follicle-Stimulating Hormone and Estradiol on Expressions of Vascular Endothelial Growth Factor (VEGF) 120, VEGF164 and Their Receptors in Bovine Granulosa Cells
• Testicular Blood Flow and Plasma Concentrations of Testosterone and Total Estrogen in the Stallion after the Administration of Human Chorionic Gonadotropin
• Comparison of Estrus Induction and Subsequent Fertility with Two Different Intravaginal Devices in Ewes during the Non-Breeding Season
• 体外受精および活性化処理されたウシ卵細胞質内カルシウムイオンの動態
• Changes in Plasma Metabolic Hormone Concentrations During the Ovarian Cycles of Japanese Black and Holstein Cattle
• In Vivo Evidence that Local Cortisol Production Increases in the Preovulatory Follicle of the Cow
• Metabolic Profiles in Ovulatory and Anovulatory Primiparous Dairy Cows During the First Follicular Wave Postpartum
• Production of Trophoblastic Vesicles Derived From Day 7 and 8 Blastocysts of In Vitro Origin and the Effect of Intrauterine Transfer on the Interestrous Intervals in Japanese Black Heifers
• ウシXY雌におけるeCG、hCG、GnRH-A投与前後の血中FSH、LH、inhibin、E2、P、T濃度の変化
• GENE EXPRESSION OF TRIPLOIDY IN SIX ADULT INTERSEXUAL CHICKENS
• FURTHER CHROMOSOMAL AND CLINICAL STUDIES ON THE XY/XYY MOSAIC BULL
• CYTOGENETICAL STUDIES ON SWINE INTERSEXES
• Changes in Follicular Vascularity during the First Follicular Wave in Lactating Cows
• 発情周期中およびプロスタグランジンF2α投与後のウシ黄体内でのアンジオポエチンと受容体TieのmRNA発現の変化:黄体退行開始機構への関与の可能性
• ウシ卵胞発育中の顆粒層細胞におけるアンジオポエチン-Tie系のmRNA発現
• Comparative Activities of Growth Hormone and Luteinizing Hormone in the Direct Stimulation of Local Release of Progesterone from Microdialyzed Ovine Corpora Lutea In Vivo
• 不妊発情周期における周期回帰のメカニズム
• Local Release of Progesterone and Oxytocin from Microdialyzed Corpus Luteum in Superovulated Ewes : Characterization during the Non-breeding Season
• Exposure of C57BL/6J Male Mice to an Electric Field Improves Copulation Rates with Superovulated Females
• Use of Contrast-Enhanced CT in the Diagnosis of Abscesses in Cattle
• Effect of an Autogenous Free Fat Graft on Hemilaminectomy Defects in Dogs
• Relationships Between the First Ovulation Postpartum and Polymorphism in Genes Relating to Function of Immunity, Metabolism and Reproduction in High-producing Dairy Cows
• 高泌乳牛の泌乳ピークと持続性が繁殖機能に及ぼす影響
• Gene Expression of 11β-HSD and Glucocorticoid Receptor in the Bovine (Bos taurus) Follicle During Follicular Maturation and Atresia : The Role of Follicular Stimulating Hormone
• Intraluteal Release of Progesterone and Prostaglandins during PGF_-Induced Luteolysis in Ewes : Local Effects of Tumor Necrosis Factor-α
• N-acetylglucosaminyltransferase I Activity of Bovine Oviduct Epithelial Cells : Stimulation by Luteinizing Hormone, Vascular Endothelial Growth Factor and Tumor Necrosis Factor α
• Detection of Zearalenone and Its Metabolites in Naturally Contaminated Porcine Follicular Fluid by Using Liquid Chromatography-Tandem Mass Spectrometry
• Detection of Early Pregnancy Factor (EPF) in Mare Sera
• Changes in Plasma Metabolic Hormone Concentrations during the Ovarian Cycles of Japanese Black and Holstein Cattle
• A FIRST CASE OF XY/XYY MOSAIC BULL
• A CHROMOSOMAL ANALYSIS BASED ON THE G AND C BAND STAINING TECHNIQUES OF THE BUFFALO (BUBALUS BUBALIS)
• ホルスタイン種乳用牛の周産期における血液と乳成分および体重の変動と分娩後の卵巣活動の関連性
• Basal Levels and GnRH-induced Responses of Peripheral Testosterone and Estrogen in Holstein Bulls with Poor Semen Quality
• Slow Recovery of Blood Glucose in Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows
• Upregulation of Interferon-stimulated Genes and Interleukin-10 in Peripheral Blood Immune Cells During Early Pregnancy in Dairy Cows
• 乳牛の分娩後早期初回排卵の有無を決定する分娩前後の栄養代謝状態
• Upregulation of Interferon-stimulated Genes and Interleukin-10 in Peripheral Blood Immune Cells During Early Pregnancy in Dairy Cows
• 乳牛の分娩後早期におけるエストラジオール処置による卵巣機能回復促進効果
• Nutritional Factors That Regulate Ovulation of the Dominant Follicle During the First Follicular Wave Postpartum in High-producing Dairy Cows
• Cloning, Monoclonal Antibody Production, and Bodily Distribution Pattern of a Bovine Lipocalin
• Cloning, Monoclonal Antibody Production, and Bodily Distribution Pattern of a Bovine Lipocalin
• Effect of the Dominant Follicle Aspiration before or after Luteinizing Hormone Surge on the Corpus Luteum Formation in the Cow
• 濃厚飼料の急激な増給や粗飼料品質変動が乳牛の健康と繁殖に及ぼす影響

もっと見る 閉じる

スポンサーリンク