Vascular Changes in the Corpus Luteum During Early Pregnancy in the Cow

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概要

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• The present study determined vascular changes in the bovine corpus luteum (CL) at Day 16 (early maternal recognition period) and Day 40 in early pregnancy and compared them to the CL from Day 12 and Day 16 of the estrous cycle. The CLs were analyzed in the central and peripheral regions, where site-depending features of vessels and angiogenic factors are evident. The same protein level of the endothelial cell marker von Willebrand factor was retained in the CL from Day 16 of the estrous cycle to Day 40 of early pregnancy. The protein level of pericytes and smooth muscle cells was determined using smooth muscle α-actin; the level decreased at Day 40 of early pregnancy in both regions of the CL. No significant change in the expressions of vascular endothelial growth factors VEGF 164 and VEGF120 mRNA occurred from Day 16 of the estrous cycle until Day 40 of early pregnancy. Angiopoietin (ANGPT)2 / ANGPT 1 mRNA ratio (an index of instability of vasculature) increased in the periphery at Day 16 of the estrous cycle and then decreased until Day 40 of early pregnancy. The results suggest that there is no difference in vascular structure between non-pregnant and pregnant luteal tissue during the early maternal recognition period (Day 16). Also, luteal rescue by early pregnancy may be not associated with further blood vessel formation but rather may be related to the decrease of blood vessels per unit of area and blood vessel stabilization in the bovine CL.

• 2010-04-01

著者

• 宮本 明夫

  帯広畜産大学畜産学部

• Miyamoto Akio

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture & Veterinary Medicine

• SHIRASUNA Koumei

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• Sasahara Kiemi

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Sasahara Kiemi

  帯広畜産大学 大学院畜産衛生学

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大

• Sasaki Motoki

  Department Of Basic Veterinary Sciences Obihiro University Of Agriculture And Veterinary Medicine

• Sasaki Motoki

  Laboratory Of Veterinary Anatomy Obihiro University Of Agriculture And Veterinary Medicine

• Shirasuna Koumei

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• Shirasuna Koumei

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• BOLLWEIN Heinrich

  Clinic for Cattle, University of Veterinary Medicine Hannover

• HERZOG Kathrin

  Clinic for Cattle, University of Veterinary Medicine Hannover

• BEINDORFF Nicola

  Clinic for Cattle, University of Veterinary Medicine Hannover

• Amaya Montoya

  帯広畜産大学 畜産学研究科畜産衛生学

• NAGAI Kaya

  Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicin

• Herzog Kathrin

  Clinic For Cattle University Of Veterinary Medicine Hannover

• Nagai Kaya

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• Bollwein Heinrich

  Clinic For Cattle University Of Veterinary Medicine Hannover

• HOEFFMANN Katharina

  Clinic for Cattle, University of Veterinary Medicine Hannover

• Sasaki Motoki

  Obihiro Univ. Agriculture And Veterinary Medicine Obihiro Jpn

• 宮本 明夫

  Graduate School Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine

• 宮本 明夫

  帯広畜産大学・畜産科学科

• Sasaki Motoki

  Department Of Basic Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine

• Beindorff Nicola

  Clinic For Cattle University Of Veterinary Medicine Hannover

• Bollwein Heinrich

  Clinic For Cattle School Of Veterinary Medicine Hannover

• Miyamoto Akio

  Graduate School Of Animal And Food Hygiene Obihiro Univ. Of Agriculture And Veterinary Medicine

• SASAKI Motoki

  Laboratory of Veterinary Anatomy, Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan

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