発情周期中およびプロスタグランジンF2α投与後のウシ黄体内でのアンジオポエチンと受容体TieのmRNA発現の変化:黄体退行開始機構への関与の可能性

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概要

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• Local angiogenesis and angiolysis in the corpus luteum (CL) relate to the luteal function. Recent studies indicate that angiopoietins (ANPT) and their receptors Tie regulate remodeling of microvasculature. We therefore examined 1) the relative changes in the expression of mRNA for ANPT-1, ANPT-2, Tie1 and Tie2 in bovine CL by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) during the estrous cycle and prostaglandin F2α (PGF2α)-induced luteolysis, and 2) the effect of ANPT-2 on progesterone (P4) release from CL at the late stage of the estrous cycle by an in vitro microdialysis system (MDS). The CLs were classified into 4 stages (early: Day 2-5, n=7, mid: Day 8-12, n=15, late: Day 15-17, n=9, regressing: Day >18, n=19). The levels of ANPT-1 mRNA in early and regressing CL were lower than those in mid and late CL, whereas ANPT-2 mRNA expression did not change during the estrous cycle. The Tie2 mRNA expression decreased as the CL aged. During PGF2α-induced luteolysis, ANPT-2 mRNA expression was acutely and temporally increased at 2 h after PGF2α injection. The expression of ANPT-1 mRNA was decreased from 4 h after PGF2α injection and kept low levels. In the experiment with the in vitro MDS, an infusion of ANPT-2 (100 ng/ml) acutely inhibited P4 release from late CL. Overall, results suggest that decrease of ANPT-1 mRNA is a basic mechanism of vascular remodeling in CL. In addition, ANPT-2 might play a role in regulation of P4 secretion in CL during luteolysis.

• 日本繁殖生物学会の論文
• 2004-12-01

著者

• Tanaka Jun

  Department of Cardiology, Tokyo Metropolitan Geriatric Hospital

• MATSUI Motozumi

  Department of Clinically Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medic

• Acosta Tomas

  Lab. Of Reproductive Endocrinology Graduate School Of Natural Sci. And Technol. Okayama Univ.

• アコスタ トマスj

  帯広畜産大学・畜産管理学科

• 小林 修一

  帯広畜産大学・畜産科学科・生殖科学研究室

• 宮本 明夫

  帯広畜産大

• Schams D

  Technical Univ. Munich Freising‐weihenstphan Deu

• Berisha B

  Technical Univ. Munich Freising‐weihenstphan Deu

• MIYAMOTO Akio

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici

• Acosta Tomas

  Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine

• BERISHA Bajram

  Institute of Physiology, Technical University of Munich

• SCHAMS Dieter

  Institute of Physiology, Technical University of Munich

• Acosta Tomas

  Graduate School Of Natural Science And Technology Okayama University

• KOBAYASHI Shuichi

  Department of Surgery III, Nara Medical University

• Matsui Motozumi

  Lab. Of Theriogenology Dep. Of Applied Veterinary Medicine Obihiro Univ. Of Agriculture And Veterina

• Schams Dieter

  帯広畜産大学 畜産科学科・生殖科学研究室

• 田中 純

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici

• TETSUKA Masa

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici

• Amaya Montoya

  帯広畜産大学 畜産学研究科畜産衛生学

• Matsui Motozumi

  Department Of Clinically Veterinary Sciences Obihiro University Of Agriculture And Veterinary Medici

• 松井 基純

  The United Graduate School Of Veterinary Sciences Gifu University

• Tetsuka Masa

  Department Of Agriculture And Life Science Obihiro University Of Agriculture And Veterinary Medicine

• Schams Dieter

  Institut Fur Physiologie Forschungszentrum Fur Milch Und Lebensmittel Weihenstephan Technische Unive

• 宮本 明夫

  帯広畜産大学・畜産科学科

• Acosta T

  Department Of Theriogenology Obihiro University Of Agriculture And Veterinary Medicine

• Miyamoto Akio

  Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin

• Kobayashi S

  Obihiro University Of Agriculture And Veterinary Medicine

• Tanaka Jun

  Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin

• Kobayashi Shuichi

  Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center

• Matsui Motozumi

  Department Of Clinical Veterinary Science Obihiro University Of Agriculture And Veterinary Medicine

• SCHAMS Dieter

  Institut für Physiologie, Süddeutsche Versuchs- und Forschungsanstalt für Milchwirtschaft, Technische Universität München

• MATSUI Motozumi

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

• ACOSTA Tomas

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

• BERISHA Bajram

  Institute of Physiology Weihenstephan, Technical University of Munich

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