Changes in the Vasculature of Bovine Corpus Luteum During the Estrous Cycle and Prostaglandin F2α-induced Luteolysis
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概要
- 論文の詳細を見る
To investigate the possible role of the vasculature in the local regulation of corpus luteum (CL) function, we determined the densities of capillaries and large blood vessels in the center of the bovine CL during the estrous cycle and following prostaglandin (PG) F2α-induced luteolysis. The CLs at the early (Days 2-3 post-ovulation), developing (Days 5-7), mid (Days 8-12), late (Days 15-17) and regressed (Days 19-21) stages were collected. In addition, the CLs were collected by transvaginal ovariectomy from 12 cows (Day 10 after ovulation), i.e., non-treated (n=3, 0 h, control), at 0.5 (n=3), 2 (n=3) and 12 h (n=3) after a luteolytic dose of PGF2α. Immunohistochemical staining with von Willebrand Factor (specific for endothelial cells that are found in both types of blood vessels) revealed that the density of the luteal blood vessels was significantly higher at the developing and late luteal stages (P<0.05) than at the other stages, whereas the number of larger blood vessels (those stained with α-smooth muscle actin) was higher at the late and regressed luteal stages (P<0.05) than at the other stages. Furthermore, both the density of blood vessels and the number of blood vessels with smooth muscle were significantly higher in the CLs obtained at 2 h and 12 h after PGF2α administration (P<0.05) than in those without PGF2α treatment. These results suggest that the number of blood vessels with smooth muscle per unit area in the regressing CL increased as a result of losing steroidogenic cells and capillaries. The overall results demonstrate that the capillaries disappeared earlier than the large blood vessels during structural luteolysis and suggest that the loss of capillaries in the CL results in a reduced supply of nutrients and oxygen to luteal cells followed by cell death.
- 日本繁殖生物学会の論文
- 2009-10-01
著者
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OKUDA Kiyoshi
Laboratory of Reproductive Endocrinology, Okayama University
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ACOSTA Tomas
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama
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Okuda Kiyoshi
Lab. Of Reproductive Endocrinology Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Okuda Kiyoshi
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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SKARZYNSKI Dariusz
Department of Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Ac
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HOJO Takuo
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama
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Acosta Tomas
Lab. Of Reproductive Endocrinology Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Acosta Tomas
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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アコスタ トマスj
帯広畜産大学・畜産管理学科
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奥田 潔
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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Acosta Tomas
Graduate School Of Natural Science And Technology Okayama University
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奥田 潔
岡山大学大学院自然科学研究科バイオサイエンス専攻生殖内分泌学
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Skarzynski Dariusz
Department Of Reproductive Immunology Institute Of Animal Reproduction And Food Research Polish Acad
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Hojo Takuo
Lab. Of Reproductive Endocrinology Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Hojo Takuo
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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Okuda Kiyoshi
Okayama Univ. Okayama
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Acosta T
Department Of Theriogenology Obihiro University Of Agriculture And Veterinary Medicine
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Skarzynski Dariusz
Dep. Of Reproductive Immunology And Pathology Inst. Of Animal Reproduction And Food Res. Polish Acad
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Hojo Takuo
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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Al-zi'abi Mohamad
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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Skarzynski Dariusz
Department Of Reproductive Immunology And Pathology Institute Of Animal Reproduction And Food Resear
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Skarzynski D
Department Of Reproductive Immunology Institute Of Animal Reproduction And Food Research Polish Academy Of Science
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ACOSTA Tomas
Laboratory of Animal Genetics and Reproduction, Obihiro University of Agriculture and Veterinary Medicine
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