牛初期胚発育に及ぼすインターフェロンτの作用
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概要
- 論文の詳細を見る
The effect of interferon-τ on in vitro development of bovine embryos was investigated. After in vitro fertilization, embryos developed to the morula stage were cultured for 3 days in TCM-199 or CR1 medium containing BSA or FCS supplemented with or without recombinant IFN-τ produced by a baculovirus expression system. Addition of baculovirus-expressed IFN-τ (100 ng/ml) significantly promoted development to the blastocyst stage in both culture media. Addition of E. coli expressed IFN-τ (2 μg/ml) also significantly promoted the embryonic development. Supplementation of BSA or FCS did not affect the growth-promoting effect of IFN-τ. To determine whether the growth-promoting effect of IFN-τ is related to the interferon type I receptors that bind to type I interferon such as IFN-α, embryos were cultured with IFN-α. Although IFN-α significantly promoted the development, a much higher concentration (25 μg/ml) was required than IFN-τ. A reverse transcription polymerase chain reaction analysis revealed the expression of mRNA encoded type-I IFN receptor subunit from morula to blastocyst stage embryos. The overall results suggest a novel function for IFNs in promoting embryonic development and the effect may be related to type-I IFN receptor expressed in the early stages of preimplantation embryos.
- 日本繁殖生物学会の論文
著者
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高橋 昌志
九州沖縄農業研究センター 暖地温暖化研究チーム
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TAKAHASHI Masashi
National Agricultural Research Center for Kyushu Okinawa Region
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Hamano Seizo
Animal Biotechnology Center Livestock Improvement Association Of Japan
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高橋 昌志
National Agricultural Research Center for Kyushu Okinawa region
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高橋 ひとみ
)National Institute of Livestock and Grassland Science
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渡辺 聡子
Animal Bio-Technology Center, Livestock Improvement Association
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WATANABE Satoko
National Institute of Animal Health
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INUMARU Shigeki
National Institute of Animal Health
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GESHI Masaya
)National Institute of Livestock and Grassland Science
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OKUDA Kiyoshi
Okayama University
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YOKOMIZO Yuichi
National Institute of Animal Health
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OKANO Akira
)National Institute of Livestock and Grassland Science
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高橋 ひとみ
農林水産省畜産試験場繁殖部
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TAKAHASHI Hitomi
)National Institute of Livestock and Grassland Science
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Okuda Kiyoshi
Okayama Univ. Okayama
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Hamano Seizo
Animal Bio-technology Center Livestock Improvement Association Of Japan Inc.
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Hamano Seizo
Animal Bio-technology Center Livestock Improvement Association
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