The inhibitory Effect of Interferon Gamma and Tumor Necrosis Factor Alpha on Intracellular Multiplication of Neospora caninum in Primary Bovine Brain Cells.
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概要
- 論文の詳細を見る
Primary culture of bovine brain cells was examined for its susceptibility to Neospora caninum infections, and this model was used to investigate the effects of bovine interferon gamma (IFN-γ) and tumor necrosis factors alpha (TNF-α) on tachyzoite growth. Tachyzoites of N. caninum grew well in this culture, and tachyzoite growth in astroglia and microglia were confirmed by immunocytochemical staining. IFN-γ inhibited the tachyzoite growth, and this inhibition was not reversed by the addition of nitric oxide antagonist. TNF-α, to a lesser extent, also inhibited the tachyzoite growth. Th-1 type cytokines may play an important role in host defense mechanisms in N. caninum infection.
- 公益社団法人 日本獣医学会の論文
著者
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YOKOMIZO Yuichi
National Institute of Animal Health
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Kitani Hiroshi
National Institute Of Agrobiological Sciences
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Shimizu Shinya
National Institute Of Animal Health
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KOKUHO Takehiro
National Institute of Animal Health
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YAMANE Itsuro
National Institute of Animal Health
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SHIMURA Kameo
National Institute of Animal Health
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HARITANI Makoto
National Institute of Animal Health
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SHIBAHARA Tomoyuki
National Institute of Animal Health, National Agriculture and Food Research Organization
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HAMAOKA Takafumi
National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba-shi, Ibaraki 305-0856, Japan
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HARITANI Makoto
National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba-shi, Ibaraki 305-0856, Japan
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KOIWAI Masahiro
National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba-shi, Ibaraki 305-0856, Japan
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SHIBAHARA Tomoyuki
National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305-0856, Japan
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SHIMURA Kameo
National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba-shi, Ibaraki 305-0856, Japan
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