日本繁殖生物学会賞・奨励賞 卵巣機能調節機構における腫瘍壊死因子の生理的役割
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概要
- 論文の詳細を見る
Tumor necrosis factor-α (TNFα) is a multifunctional cytokine that was first described as a tumoricidal factor produced by activated macrophages. Extensive research over the last two decades has suggested that TNFα has physiologically diverse actions in ovarian function in a variety of species. TNFα and its specific receptors are present in the ovaries of many species. Furthermore, TNFα plays multiple and probably important roles in corpus luteum (CL) function as well as ovarian cell function throughout the estrous cycle. This review focuses on recent studies documenting TNFα in ovarian follicles and CL in several mammals. In addition, possible roles of TNFα in ovarian function throughout the estrous cycle and in the gestation period are discussed.
- 日本繁殖生物学会の論文
著者
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OKUDA Kiyoshi
Laboratory of Reproductive Endocrinology, Okayama University
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Okuda Kiyoshi
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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作本 亮介
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences
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奥田 潔
Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University
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奥田 潔
Laboratory Of Reproductive Endocrinology Graduate School Of Natural Science And Technology Okayama U
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Sakumoto Ryosuke
Department Of Physiology And Genetic Regulation National Institute Of Agrobiological Sciences
関連論文
- Effects of Tumor Necrosis Factor α and Interferon γ on the Viability and mRNA Expression of TNF Receptor Type I in Endothelial Cells from the Bovine Corpus Luteum
- Gene Expression of 11β-HSD and Glucocorticoid Receptor in the Bovine (Bos taurus) Follicle During Follicular Maturation and Atresia: The Role of Follicular Stimulating Hormone
- Changes in the Levels of Progesterone Receptor mRNA and Protein in the Bovine Corpus Luteum During the Estrous Cycle
- Expression of VEGF and Its Receptors in the Bovine Endometrium Throughout the Estrous Cycle : Effects of VEGF on Prostaglandin Production in Endometrial Cells
- Role of Nitric Oxide in the Regulation of Superoxide Dismutase and Prostaglandin F_ Production in Bovine Luteal Endothelial Cells
- 一酸化窒素(NO)はウシ黄体細胞のアポトーシスを誘導する
- 日本繁殖生物学会賞・奨励賞 卵巣機能調節機構における腫瘍壊死因子の生理的役割
- ウシ顆粒層細胞および卵胞膜内膜細胞における腫瘍壊死因子(TNFα)受容体
- Expression and Localization of cFLIP, an Anti-apoptotic Factor, in the Bovine Corpus Luteum
- Species-Related Differences in the Mechanism of Apoptosis During Structural Luteolysis
- Luteotropic Mechanisms in the Bovine Corpus Luteum : Role of Oxytocin, Prostaglandin F_, Progesterone and Noradrenaline
- Acute Changes in Circulating Concentrations of Progesterone and Nitric Oxide and Partial Pressure of Oxygen During Prostaglandin F_-induced Luteolysis in Cattle
- Changes in the Vasculature of Bovine Corpus Luteum During the Estrous Cycle and Prostaglandin F2α-induced Luteolysis
- Possible Roles of Intracellular Cyclic AMP, Protein Kinase C and Calcium Ion in the Apoptotic Signaling Pathway in Bovine Luteal Cells
- Prostaglandin F_ Regulates the Nitric Oxide Generating System in Bovine Luteal Endothelial Cells
- 正常発情周期中のブタ子宮内膜ではトロフィニンが発現している
- ホルスタイン種雄牛の加齢にともなう血中ホルモン濃度の変化
- Nitric oxide in bovine corpus luteum : Possible mechanisms of action in luteolysis
- ウシ黄体における黄体形成ホルモン(LH)のホスホリパーゼCを介したプロジェステロン分泌促進機構に関する研究
- ウシ黄体細胞のプロスタグランジン産生におよぼす線維芽細胞成長因子の影響とその細胞内シグナル伝達経路
- Phyto- and Endogenous Estrogens Differently Activate Intracellular Calcium Ion Mobilization in Bovine Endometrial Cells
- Hypoxia is Important for Establishing Vascularization During Corpus Luteum Formation in Cattle
- Regulation of uterine function by cytokines in cows : Possible actions of tumor necrosis factor-α, interleukin-1α and interferon-τ
- Hypoxia is Important for Establishing Vascularization During Corpus Luteum Formation in Cattle
- Gene Silencing of Cyclooxygenase-2 mRNA by RNA Interference in Bovine Cumulus-Granulosa Cells
- Development and Evaluation of a Rapid Enzyme-immunoassay System for Measurement of the Urinary Concentration of Estrone-3-glucuronide in a Female Giant Panda (Ailuropoda melanoleuca)
- Effects of Prostaglandin F_ and Nitric Oxide on the Secretory Function of Bovine Luteal Cells
- Effects of Nitric Oxide and Tumor Necrosis Factor-α on Production of Prostaglandin F_ and E_2 in Bovine Endometrial Cells
- Progesterone Stimulation by LH Involves the Phospholipase-C Pathway in Bovine Luteal Cells
- Progesterone Stimulation by Prostaglandin F2α Involves the Protein Kinase C Pathway in Cultured Bovine Luteal Cells
- Age-Related Changes in the Serum Levels of Inhibin, FSH, LH and Testosterone in Holstein Bulls
- Basic Fibroblast Growth Factor-Induced Prostaglandin Production and Its Intracellular Mechanisms in Cultured Bovine Luteal Cells
- MECHANISM IN THE REGULATION OF OVARIAN CYCLE : REGULATION OF ENDOMETRIAL PROSTAGLANDIN F_ SYNTHESIS IN LUTEOLYSIS IN CATTLE
- Expressions of Estrogen Receptors in the Bovine Corpus Luteum : Cyclic Changes and Effects of Prostaglandin F2α and Cytokines
- Role of Nitric Oxide in the Regulation of Superoxide Dismutase and Prostaglandin F2α Production in Bovine Luteal Endothelial Cells
- ウシ子宮内膜の上皮細胞および間質細胞の単離・継代・凍結保存法の開発
- Effects of Tumor Necrosis Factor α and Interferon γ on the Viability and mRNA Expression of TNF Receptor Type I in Endothelial Cells from the Bovine Corpus Luteum
- Progesterone Stimulation by Prostaglandin F_ Involves the Protein Kinase C Pathway in Cultured Bovine Luteal Cells
- Secretion of Prostaglandins E_2 and F_ by the Bovine Endometrium in Response to Oxytocin during the Estrous Cycle
- Epidermal Growth Factor and Its Receptor in Bovine Corpus Luteum during the Estrous Cycle
- Gene Expression of 11β-HSD and Glucocorticoid Receptor in the Bovine (Bos taurus) Follicle During Follicular Maturation and Atresia : The Role of Follicular Stimulating Hormone
- Effects of Storage and Passage of Luteal Endothelial Cells on Endothelin-1 and Prostaglandin F2α Production
- Effects of Cortisol on Pregnancy Rate and Corpus Luteum Function in Heifers : An In Vivo Study
- Seasonal Changes in Luteal Progesterone Concentration and mRNA Expressions of Progesterone Synthesis-related Proteins in the Corpus Luteum of Mares
- Seasonal Changes in Luteal Progesterone Concentration and mRNA Expressions of Progesterone Synthesis-related Proteins in the Corpus Luteum of Mares
- Possible Role of Insulin-Like Factor 3 in the Bovine Corpus Luteum
- Luteoprotective Mechanisms of Prostaglandin F2α Stimulated by Luteinizing Hormone in the Bovine Corpus Luteum
- Induction of the Expressions of Antioxidant Enzymes by Luteinizing Hormone in the Bovine Corpus Luteum
- Acute Changes in Circulating Concentrations of Progesterone and Nitric Oxide and Partial Pressure of Oxygen During Prostaglandin F2.ALPHA.-induced Luteolysis in Cattle
- Biological Activity of Recombinant Bovine Interferon τ Produced by a Silkworm-Baculovirus Gene Expression System