A Quantity of Stereotyped Behavior of ddY Mice Induced by Low-dose Methamphetamine
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概要
- 論文の詳細を見る
It is reported that high-dose methamphetamine (8 mg/kg) induces stereotyped behavior in ddY mice in an open field, but itis still not certain that low-dose methamphetamine (less than 2 mg/kg) can induce the stereotyped behavior in ddY mice in a narrow space. In order to investigate the problem, we evaluated the quantity of stereotyped behavior of ddY mice by using a mouse wheel-running apparatus. In this method, we have come to recognize an increase in the stereotyped behavior depending on the dose of methamphetamine and the reverse-tolerance phenomenon as a decrease in the wheel-revolution counts. The present findings indicate that low-dose methamphetamine can promote stereotyped behavior in ddY mice under conditions in which the ambulation is restricted to a narrow wheel space.
- 社団法人 日本実験動物学会の論文
著者
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Masuda Yutaka
Department of Agricultural Chemistry, The University of Tokyo
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Shimizu Tetsuo
Department Of Psychiatry Akita University School Of Medicine
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HISHIKAWA YASUO
Department of Neuropsychiatry, Akita University School of Medicine
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Hishikawa Yasuo
Department Of Neuropsychiatry Akita University School Of Medicine
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MATSUDA Yukihisa
Animal Facilities for Experimental Medicine, Akita University School of Medicine
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KONHOH Masato
Department of Neuropsychiatry, Akita University School of Medicine
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Kondoh Masato
Department Of Applied Biochemistry Faculty Of Applied Biological Science Hiroshima University
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Konhoh Masato
Department Of Neuropsychiatry Akita University School Of Medicine
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Shimizu Tetsuo
Department Of Neuropsychiatry Akita University Hospital
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Masuda Yutaka
Deparmtent Of Cardiovascular Surgery Institute Of Health Biosciences University Of Tokushima Graduat
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Shimizu Tetsuo
Department Of Electrical Engineering Nagaoka University Of Technology
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SHIMIZU Tetsuo
Department of Civil Engineering The University of Tokyo
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