Influence of Lymphocytes in Malignant Pleural Effusion on the Therapeutic Efficacy of Intrapleural OK-432 in Lung Cancer Patients
スポンサーリンク
概要
- 論文の詳細を見る
Objectives: Malignant pleural effusion, a common complication seen in advanced lung cancer patients, is often treated with intrapleural administration of chemical agents. In Japan, OK-432, a biological response modifiers, which activates the cytotoxic activity of lymphocytes and boosts antitumor immunity, is among the most frequently used chemical agents. The purpose of this study was to determine, in a case-control study, whether or not the rate of lymphocytes in malignant pleural effusion (lymphocyte rate) influences the therapeutic efficacy of intrapleural OK-432. Patients and Methods: We enrolled 20 lung cancer patients with malignant pleural effusion treated with intrapleural OK-432 who were admitted to our hospital between January 2000 and December 2004. Therapeutic efficacy was assessed from the response rate, duration of chest drainage after treatment with intrapleural OK-432, time to progression of malignant pleural effusion, and survival time. Results: Response rate in patients who had a high lymphocyte rate (the High lymphocyte rate group) was significantly higher than in patients who had a low lymphocyte rate (the Low lymphocyte rate group). Lymphocyte rate did not correlate with duration of chest drainage after treatment with intrapleural OK-432, time to progression of malignant pleural effusion, or survival time. Conclusions: The lymphocyte rate in malignant pleural effusion influences the response rate to treatment by intrapleural OK-432. In the High lymphocyte rate group, intrapleural OK-432 for malignant pleural effusion was effective. We conclude that intrapleural OK-432 is useful for malignant pleural effusion patients with a high lymphocyte rate before treatment.
- 社団法人 日本内科学会の論文
著者
-
Horie Takashi
Department Of Cardiovascular Medicine Shinshu University Graduate School Of Medicine
-
SHIMIZU Tetsuo
Department of Civil Engineering The University of Tokyo
-
Tsujino Ichiro
Department of Respiratory Medicine, Nihon University School of Medicine
-
Takahashi Noriaki
Department of Respiratory Medicine, Nihon University School of Medicine
-
Takahashi Noriaki
Department of Chemistry, Faculty of Science, University of Tokyo
-
Terakado Masahiro
Department of Respiratory Medicine, Nihon University School of Medicine
-
Akusawa Hiroshi
Department of Respiratory Medicine, Nihon University School of Medicine
-
Horie Takashi
Department of Respiratory Medicine, Nihon University School of Medicine
関連論文
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- Adult Kawasaki Disease Unrelated to Epstein-Barr Virus and Group A Streptococcus
- Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives
- Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
- Genetic Variations of CYP2C9 in 724 Japanese Individuals and Their Impact on the Antihypertensive Effects of Losartan
- Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene
- IS005 Vascular Smooth Muscle Cell(VSMC)-Specific Overexpression of Angiotensin type2(AT2)Receptor Causes Endothelium-dependent Vasodilation via bradykinin/NO/cGMP pathway
- IS104 Cell-specific Distribution of Angiotensin II Receptor Subtypes and Receptors-mediated Biochemical Changes in Failing Human Hearts
- IS040 Angiotensin Type 2 (AT2) Receptor Inhibits AT1-mediated Intracelluar Alkalosis to Enhance Kinik Production in Vascular Smooth Muscle Cells From Vascular-targeted AT2 Transgenic Mice
- IS050 Cardiac-Specific Overexpression of Angiotensin AT2 receptor Causes Attenuated Response to AT1 receptor - Mediated Chronotropic Action
- PJ-708 Postchallenge Hyperglycemia is an Independent Risk Factor for Left Ventricular Hypertrophy in Non-diabetic Hypertensive Patients(Hypertension, clinical(09)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation S
- Brain metastasis of a papillary renal cell carcinoma, identified as type 2
- OE-140 Impact of Diabetes and Chronic Kidney Disease on Preloadinduced Changes in Left Ventricular Diastolic Filling in Hypertensive Patients(Hypertension, clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circu
- 5 Autologous Mononuclear Cell Implantation Therapy for Critical Digit Ischemia in Patients with Connective Tissue Diseases(Regenerative Therapy for Peripheral Artery Disease,Symposium 12 (SY-12) (I),The 73rd Annual Scientific Meeting of The Japanese Circu
- OE-136 Prognostic Value of Combination of Adrenomedullin and Brain Natriuretic Peptide in Patients with Stable Cardiovasculer Disease(OE23,Heart Failure (Pathophysiology) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese C
- Subclinical renal tubular acidosis in patients with primary and secondary Sjogren's syndrome : a possible marker of disease progression
- Genetic Polymorphisms of L-Type Calcium Channel α1c and α1D Subunit Genes are Associated With Sensitivity to the Antihypertensive Effects of L-Type Dihydropyridine Calcium-Channel Blockers
- Increased Number of Hematopoietic Stem Cells in Adherent Layer of Bone Marrow Cell Culture with Stroma by Treatment with Granulocyte Colony-Stimulating Factor
- Effect of Statin Therapy on In-stent Neointimal Proliferation after Coronary Stent Implantation ; 3D-Volumetric Intravascular Ultrasound Study (Restenosis after Angioplasty, Basic/Clinical 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circul
- Relationship between Effectiveness of Statin Therapy on In-stent Restenosis and Arterial Remodeling in Patients with Acute Coronary Syndrome ; 3D-IVUS Study(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 2 (IHD), The 69th Annual Scientif
- Inflammation May Lead to the Development of Coronary Spasm
- Preinterventional Coronary Artery Remodeling Influences In-Stent Restenosis : A 3D-Volumetric Intravascular Ultrasound Analysis
- 6 Therapeutic Angiogenesis by Mononuclear Cell Implantation for Critical Digit Ischemia of Patients with Connective Tissue Diseases : a Multicenter Clinical Trial(Symposium 12 (SY-12) (M) Clinical Experiences of Regenerative Medicine in Cardiovascular Dis
- Therapeutic Angiogenesis for Patients with Limb Ischemia by Autologous Transplantation of Bone Marrow Cells : Randomized Controlled Trial
- Angiogenesis for Critical Limb Ischemia Using Autologous Bone Marrow Cell Transplantation
- OE-308 C-Terminal Endothelin-1 Precursor Fragment (CT-proET-1) Reflects Cardiac Dysfunction in Hemodialysis Patients with Cardiovascular Disease(OE52,Kidney/Renal Circulation/CKD 2 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- OJ-208 Which Blood Pressure is the Most Powerful Predictor of Hypertensive Multiple Organ Damages?(Hypertension, clinical(03)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- C-Reactive Protein, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension
- The Incidence and Risk Factors of Renal Artery Stenosis in Patients with Severe Carotid Artery Stenosis
- Effect of Early Nephrology Referral on the Initiation of Hemodialysis and Survival in Patients With Chronic Kidney Disease and Cardiovascular Diseases
- Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects
- 霧化型励起酸素発生器の基礎研究III
- PJ-119 Effect of Anti-platelet Drugs at Angiogenic Cell Therapy(Peripheral circulation-8 (H) PJ20,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Anti-platelet Drugs Inhibited Angiogenesis by Bone Marrow Cell Implantation(Peripheral Circulation/Vascular Disease (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Therapeutic Angiogenesis Therapy by Autologous Bone Marrow Cell Transplantation for Critical Limb Ischemia(An Update on the Contemporary Management of Peripheral Arterial Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiogenesis and Angiotensin II : Differential Postnatal Angiogenic Activities Unmasked by Gene-Engineered Mouse Models of Angiotensin AT1 and AT2 Receptor Subtypes
- No Association of the G1287A Polymorphism in the Norepinephrine Transporter Gene and Susceptibility to Major Depressive Disorder in a Japanese Population(Biopharmacy)
- Scattering and Polarization of 57-MeV Protons
- PE-120 Reduced Systolic Strain at Left Ventricular Posterior Wall in Patients with Duchenne Muscular Dystrophy(Echo/Doppler 5 (I) : PE21)(Poster Session (English))
- Viral Infection in Asthma
- Effects of Yoku-kan-san-ka-chimpi-hange on the sleep of normal healthy adult subjects
- Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low in patients with Guillain-Barre syndrome
- Sleep habits of students attending elementary schools, and junior and senior high schools in Akita prefecture
- Sleep-disordered breathing in a patient with congenital myopathy
- Prevalence of sleep-related respiratory disorders in 101 schizophrenic inpatients
- Muscle sympathetic nerve activity during central, mixed and obstructive apnea : Are there any differences?
- Effects of the Combination of Hypertension and Diabetes Mellitus on Left Ventricular Systolic Function(Echo/Doppler 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Induction of adipogenesis by the intrasplenic transplantation of chick serum clots
- High-Performance Liquid Chromatographic Determination of Fluvoxamine and Fluvoxamino Acid in Human Plasma
- Elastic and Inelastic Scattering of 22.2 MeV Alpha Particles from Some Medium-Weight Nuclei
- PJ-024 Relations of Left Ventricular Geometric Patterns to Left Ventricular Systolic and Diastolic Function in Patients with Systemic Hypertension(Echo/Doppler-15 (I) PJ4,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japa
- Follow-up Study of'Moyamoya'in Adult Patients
- The Fragment of Complement 3a Lacking the Primary 9 Amino Acids Induces Promoting Activity on Mouse Voluntary Running
- Clinical differences between brain natriuretic peptide and N-terminal pro-brain natriuretic peptide
- A Quantity of Stereotyped Behavior of ddY Mice Induced by Low-dose Methamphetamine
- Situs Inversus Totalis with Malignant Lymphoma of the Stomach : Report of a Case
- Adrenal Metastasis from Rectal Cancer : Report of a Case
- Multibacterial Sepsis in an Alcohol Abuser with Hepatic Cirrhosis
- Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension
- Gamma Deexcitation Mechanism of Rare-Earth Compound Nuclei Produced by (^3He,xn) and (α,xn) Reactions
- FAILURE OF DIBUTYRYL AND 8-BROMO-CYCLIC GMP TO MIMIC THE ANTAGONISTIC ACTION OF CARBACHOL ON THE POSITIVE INOTROPIC EFFECTS OF SYMPATHOMIMETIC AMINES IN THE CANINE ISOLATED VENTRICULAR MYOCARDIUM
- Pharmacological Mechanism in Slip-Down Behavior of Mice
- A negative component superimposed on event-related potentials during light drowsiness
- Direct Evidence for a Charge-Controlled Optical Quernching of EL2 Centers in Semi-Insulating GaAs
- Study of (d,α) Reactions on ^Ca and ^Ar
- The High Excited Levels of ^Al
- Excited States in ^Ar from Inelastic Alpha-Particle Scattering
- Suicide patterns and characteristics in Akita, Japan
- CSF HYPOCRETIN CONCENTRATION IN VARIOUS NEUROLOGICAL AND SLEEP DISORDERS
- A-7-5 The Braid Conjugacy Problem and Group Representations over Cyclotomic Fields
- A CASE WITH HYPOCRETIN(OREXIN) DEFICIENT NARCOLEPSY, PARKINSON'S DISEASE AND SEVERE PSYCHOSIS WAS SUCCESSFULLY TREATED BY MODIFIED ELECTRO-CONVULSIVE THERAPY
- SIX CASES SUSPECTED OF HAVING INSUFFICIENT SLEEP SYNDROME IN OUR CLINIC
- Inter-Regional Travel Demand Analysis Using Integrated Model For Practical Travel Demand Forecast
- Guidelines for Smoking Cessation (JCS 2010) : Digest Version
- Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
- Semi-Nested Real-Time Reverse Transcription Polymerase Chain Reaction Methods for the Successful Quantitation of Cytokeratin mRNA Expression Levels for the Subtyping of Non-Small-Cell Lung Carcinoma Using Paraffin-Embedded and Microdissected Lung Biopsy S
- SYMPATHETIC AND PARASYMPATHETIC CONTROL OF HEART RATE RESPONSE TO RESTRAINT STRESS DURING THE VULNERABLE PERIOD IN NEWBORN RATS
- Influence of Lymphocytes in Malignant Pleural Effusion on the Therapeutic Efficacy of Intrapleural OK-432 in Lung Cancer Patients
- Solvent inclusion effects on the structure and electrical conductivity of benzidine-TCNQ complex.