Sequence Variants at the myostatin Gene Locus Influence the Body Composition of Thoroughbred Horses
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概要
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Myostatin is a member of the transforming growth factor-β family with a key role in inhibition of muscle growth by negative regulation of both myoblast proliferation and differentiation. Recently, a genomic region on ECA18, which includes the MSTN gene, was identified as a candidate region influencing racing performance in Thoroughbreds. In this study, four SNPs on ECA18, g.65809482T>C, g.65868604G>T, g.66493737C>T, and g.66539967A>G, were genotyped in 91 Thoroughbred horses-in-training to evaluate the association between genotype and body composition traits, including body weight, withers height, chest circumference, cannon circumference, and body weight/withers height. Of these, statistically differences in body weight and body weight/withers height were associated with specific genotypes in males. Specifically, body weight/withers height showed statistically significant differences depending on genotype at g.658604G>T, g.66493737C>T, and g.66539967A>G (P<0.01) in males during the training period. Animals with a genotype associated with suitability for short-distance racing, C/C at g.66493737C>T, had the highest value (3.17 ± 0.05 kg·cm-1) for body weight/withers height in March, while those with a genotype associated with suitability for long-distance racing, T/T, had the lowest (2.99 ± 0.03 kg·cm-1). In females, the trends in the association of body weight/withers height with genotypes were similar to those observed in males. As the SNPs are not believed to be linked to coding variants in MSTN, these results suggest that regulation of MSTN gene expression influences skeletal muscle mass and hence racing performance, particularly optimum race distance, in Thoroughbred horses.
著者
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Hirota Kei-ichi
Department of Molecular Genetics, Laboratory of Racing Chemistry
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Kakoi Hironaga
Department of Genetic Analysis, Laboratory of Racing Chemistry
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Gawahara Hitoshi
Department of Genetic Analysis, Laboratory of Racing Chemistry
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TOZAKI Teruaki
Department of Molecular Genetics, Laboratory of Racing Chemistry
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Nambo Yasuo
Hidaka
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Nakano Yasuko
Department Of Medicinal Information School Of Pharmaceutical Sciences Showa University
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KUROSAWA Masahiko
Department of Genetic Diagnostics, Laboratory of Racing Chemistry
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Gawahara Hitoshi
Department Of Blood Typing Laboratory Of Racing Chemistry
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Miyake Takeshi
Comparative Agricultural Sciences Graduate School Of Agriculture Kyoto University
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Sato Fumio
Hidaka Training And Res. Centre Japan Racing Assoc.
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Endo Yoshiro
Hidaka Training And Research Center Jra
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NAMBO Yasuo
Hidaka Training and Research Centre, Japan Racing Association
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HILL Emmeline
Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin
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KUROSAWA Masahiko
Department of Molecular Genetics, Laboratory of Racing Chemistry
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Nakano Yasuko
Department of Chemistry, Faculty of Science, Hokkaido University
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ENDO Yoshiro
Hidaka Training and Research Centre, Japan Racing Association
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