Effect of Progesterone on the in vitro Response of Peripheral Blood Mononuclear Cells Stimulated by Escherichia coli in Mares
スポンサーリンク
概要
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Escherichia coli(E. coli) isolated from the uterus of a Thoroughbred mare with bacterial endometritis was used to evaluate the effect of progesterone (P4) on the immune response of mares. Peripheral blood mononuclear cells (PBMCs) were collected from 10 nonpregnant clinically healthy adult mares (range, 4-12 years) during diestrus, four Thoroughbreds and six Hokkaido native horses. Cell proliferation and expression of cytokine mRNA, including interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-10, of PBMCs stimulated with E. coli and P4 were examined in vitro. P4 was shown to have significantly inhibited E. coli induced proliferation and expression of IFN-γ in PBMCs. These results indicate that P4 inhibits the immune response to E. coli in mares.
著者
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Ohtsuka Hiromichi
School Of Veterinary Medicine Kitasato University
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Nambo Yasuo
Hidaka
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TOMIOKA Michiko
School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 Bancho, Towada, Aomori 034-8628, Japan
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OIKAWA Masa-aki
School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 Bancho, Towada, Aomori 034-8628, Japan
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MAEDA Yousuke
School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 Bancho, Towada, Aomori 034-8628, Japan
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TANABE Taishi
School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 Bancho, Towada, Aomori 034-8628, Japan
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UEMATSU Haruki
Yoshizawa Stable Fukushima,1 Nakasone, Aza-ogawa, Tenei-mura, Iwase-gun, Fukushima 962-0516, Japan
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TANABE Taishi
School of Veterinary Medicine, Kitasato University
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