Comparison of the Immunosuppressive Effects of Dexamethasone, Flunixin Meglumine, and Meloxicam on the In Vitro Response of Calf Peripheral Blood Mononuclear Cells
スポンサーリンク
概要
- 論文の詳細を見る
This study compared the immunosuppressive effects of dexamethasone (DEX), flunixin meglumine (FLU), and meloxicam (MEL) on the peripheral blood mononuclear cells (PBMCs) of seven healthy Holstein calves in vitro. DEX significantly inhibited lymphocyte proliferation and expression of interferon (IFN)-γ, interleukin (IL)-2, and IL-4 messenger RNA (mRNA) in comparison to FLU and MEL. FLU and MEL dose-dependently inhibited lymphocyte proliferation, but did not significantly reduce mRNA expression. Our in vitro study indicates that steroidal anti-inflammatory drugs (SAIDs) as well as non-steroidal anti-inflammatory drugs (NSAIDs) have immunosuppressive effects on calf PBMCs. These findings are important for assessing the indications and complications of NSAIDs in calves.
著者
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OIKAWA Masaaki
School of Veterinary Medicine, Kitasato University
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Ohtsuka Hiromichi
School Of Veterinary Medicine Kitasato University
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MAEDA Yousuke
School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 Bancho, Towada, Aomori 034-8628, Japan
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TANABE Taishi
School of Veterinary Medicine, Kitasato University
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TANAKA Rie
School of Veterinary Medicine, Kitasato University
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MATSUDA Keiici
Chuou Veterinary Clinical Center, Miyagi Prefecture Federation of Agricultural Mutual Relief Association
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MAEDA Yousuke
School of Veterinary Medicine, Kitasato University
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