Measurement of Oxidative Stress in the Rodent Brain Using Computerized Electron Spin Resonance Tomography
スポンサーリンク
概要
- 論文の詳細を見る
The strategy of this study was to improve the electronic spin resonance (ESR) application used to detect free radical-induced oxidative stress in animal models. We have developed an in vivo ESR imaging system with high-quality ESR-computed tomography (CT) images by using a nitroxyl spin probe—BBB-permeable, 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-yloxy (MC-PROXYL)—in living small animals. We first measured the distribution of MC-PROXYL in the head region of a living mouse by using ESR-CT imaging after treatment with MC-PROXYL. In the ESR-CT experiments, it was clearly observed that MC-PROXYL was well distributed in the brain of head region of a living mouse. The ESR-CT images taken after treatment with MC-PROXYL demonstrate that the decay of MC-PROXYL in the isolated brain of a spontaneously hypertensive rat (SHR) was more rapid than that in a Wister Kyoto rat. ESR-CT analysis revealed that the region of rapid decay might be located in the cerebral cortex of the isolated brain of an SHR. These results suggest that the present study of ESR-CT imaging would be a useful tool for monitoring and detecting the locations of oxidative stress in the brains of rodent animal models.
- 日本磁気共鳴医学会の論文
- 2003-07-01
著者
-
Lee Masaichi-chang-il
神奈川歯科大学 薬理学
-
Ikeda Yukio
Department Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University
-
Ikeda Yukio
Department Of Earth Sciences Ibaraki University
-
Anzai Kazunori
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
-
Anzai Kazunori
National Institute Of Radiological Sciences
-
OZAWA Toshihiko
National Institute of Radiological Sciences
-
Miyazaki Hiroyuki
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases
-
Lee Masaichi-chang-il
Department Of Clinical Care Medicine Division Of Pharmacology And Esr Laboratories
-
Miyazaki Hiroyuki
Department Of Clinical Care Medicine Division Of Pharmacology And Esr Laboratories
-
Hori Norio
Department Of Oral And Maxillofacial Rehabilitation Division Of Prosthetics Kanagawa Dental College
-
SHOJI Hirofumi
Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories
-
YOSHINO Fumihiko
Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories
-
MIYAKE Shinjiro
Department of Orthodontics, Kanagawa Dental College
-
Shoji Hirofumi
Department Of Clinical Care Medicine Division Of Pharmacology And Esr Laboratories
-
Shoji Hirofumi
Department Of Biotechnology Graduate School Of Engineering Osaka University
-
Yoshino Fumihiko
Div. Of Pharmacology And Esr Laboratories Dep. Of Clinical Care Medicine Kanagawa Dental Coll. Jpn
-
Ikeda Yukio
Department Of Earth Sciences Faculty Of Science Ibaraki University
-
Ikeda Yukio
Department Of Neurosurgery Tokyo Medical University Hachioji Medical Center
-
Ozawa Toshihiko
National Institute Of Radiological Science
-
Miyake Shinjiro
Department Of Orthodontics Kanagawa Dental College
-
Yoshino Fumihiko
Department Of Pharmacology And Esr Laboratories Kanagawa Dental College
-
Lee Masaichi-chang-il
Department Of Pharmacology And Esr Laboratories Kanagawa Dental College
-
Miyazaki Hiroyuki
Department Of Agricultural Chemistry The University Of Tokyo:(present Office)pharmaceutical Research
-
Ikeda Yukio
Department Of Earth Science Faculty Of Science Ibaraki University
関連論文
- Intracellular and Extracellular Redox Environments Surrounding Redox-Sensitive Contrast Agents under Oxidative Atmosphere(Analytical Biochemistry)
- Detection of Free Radical Reactions in an Aqueous Sample Induced by Low Linear-Energy-Transfer Irradiation(Analytical Biochemistry)
- Scandium Ion-accelerated Scavenging Reaction of Cumylperoxyl Radical by a Cyclic Nitroxyl Radical via Electron Transfer
- Involvement of Electron Transfer in the Radical-scavenging Reaction of Resveratrol
- Effect of Solvent Polarity on the One-electron Oxidation of Cyclic Nitroxyl Radicals
- Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain
- Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow
- Pancreatic Arteriovenous MalformationCombined with Portal Thrombosis
- Relationship between Effects of Phenolic Compounds on the Generation of Free Radicals from Lactoperoxidase-Catalyzed Oxidation of NAD(P)H or GSH and their DPPH Scavenging Ability
- Transport of the Cu(II) Bound with Histidine-Containing Tripeptides to Cysteine. Coordination Mode and Exchangeability of Cu(II) in the Complexes
- Vitamin E-Deficiency Did Not Exacerbate Partial Skin Reactions in Mice Locally Irradiated with X-rays
- Major-element trend for shergottite melts and their source materials
- High Glucose Induces Transactivation of the α2-HS Glycoprotein Gene Through the ERK1/2 Signaling Pathway
- Muscle Strength is a Marker of Insulin Resistance in Patients with Type 2 Diabetes : A Pilot Study
- Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes
- Serum Paraoxonase(PON1) Concentration in Patients Undergoing Hemodialysis
- A Polymorphism in the Promoter Region of the Glucocorticoid Receptor Gene Is Associated with Its Transcriptional Activity
- Clinical Significance of the Insulin Resistance Index as Assessed by Homeostasis Model Assessment
- Serum Paraoxonase and Arylesterase Activities in Hemodialysis Patients
- Urinary prostacyclin metabolites in patients with IgA nephropathy
- Severe Diabetic Scleredema with Extension to the Extremities and Effective Treatment Using Prostaglandin E_1
- Trp64Arg Mutation of β_3-Adrenergic Receptor and Insulin Sensitivity in Subjects with Glucose Intolerance
- Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography(HPLC)(Analytical Biochemistry)
- Enhanced Membrane-Perturbing Activities of Bundled Amphiphilic α-Helix Polypeptides on Interaction with Phospholipid Bilayer
- Hemangioblastomas with Blood Supply from the Dural Arteries : Two Case Reports
- X-Ray Study of the Distant QSO PKS 0237-233 with ASCA and ROSAT
- Heat-Treated Mineral-Yeast as a Potent Post-irradiation Radioprotector
- Quantitative Measurements of Oxidative Stress in Mouse Skin Induced by X-Ray Irradiation
- Petrology of a new basaltic shergottite: Dhofar 378
- Antarctic howardites and their primitive crust
- Chemical compositions of matrices of unequilibrated ordinary chondrites
- Toxic Interactions between Disopyramide and Propranolol in Chick Embryos
- Fatal Severe Vasospasm Due to Rewarming Following Hypothermia
- Inverted ductal papilloma of minor salivary gland : Case report with immunohistochemical study and literature review
- Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain
- Potent 2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Activity of Novel Antioxidants, Double-Stranded Tyrosine Residues Conjugating Pyrocatechol
- Comparative study on the major element chemical compositions of Antarctic chondrites to those of non-Antarctic falls with reference to terrestrial weathering
- Yamato nakhlites: Petrography and mineralogy
- Petrology and chemistry of the Miles IIE iron. II: Chemical characteristics of the Miles silicate inclusions
- Petrology and chemistry of the Miles IIE iron. I: Description and petrology of twenty new silicate inclusions
- Yamato-791093, a metal-sulfide-enriched H-group chondritic meteorite transitional to primitive IIE irons with silicate inclusions
- New enclaves in the Vaca Muerta mesosiderite: Petrogenesis and comparison with HED meteorites
- Enclaves in the Mt.Padbury and Vaca Muerta mesosiderites: Magmatic and residue (or cumulate) rock types
- N-2-Mercaptopropionyl Glycine Blocks Ischemic Tolerance and Synthesis of Heat Shock Protein 70 in Rabbit Hearts
- Mineralogy of Antarctic aubrites, Yamato-793592 and Allan Hills-78113: Comparison with non-Antarctic aubrites and E-chondrites
- Oxidative Stress Markers
- Oxidative stress and temporomandibular joint disorders
- Synthesis of Transmembrane Segment Peptides and Its Analogs of A Single Spanning Protein, Isk, Forming Potassium Channel and Its Channel Formation Activity
- Studies on Association Behavior of Transmembrane Segment of Influenza Virus M2 Protein in Lipid Bilayers
- Petrology of silicate inclusions in the Miles IIE iron
- Lithic and mineral clasts in the Dar Al Gani (DAG) 319 polymict ureilite
- Specific Excretion into the Medium of a Serine Protease from Serratia marcescens(Microbiology & Fermentation Industry)
- Comparative Studies on the Stability of a Chelate-Ring Unit in Dynamic Aspects. Chelate-Rings of the Cu(II) Complexes Composed of [N-(Glycyl)], [N-(β-Alanyl)], and [N-(2-Aminoethyl)] Moieties
- Assessment of Oxidative Stress in the Spontaneously Hypertensive Rat Brain Using Electron Spin Resonance (ESR) Imaging and in Vivo L-Band ESR
- Measurement of Oxidative Stress in the Rodent Brain Using Computerized Electron Spin Resonance Tomography
- A Study of the Effects of Irradiation on the Polymerization of Dual-cured Self-etching Bonding System Using Electron Spin Resonance (ESR) Spectroscopy
- A Study of the Effects of Self-etching Primers on the Polymerization of Bonding Agents Using Electron Spin Resonance (ESR) Spectroscopy
- REACTIONS OF SUPEROXIDE ION WITH Cr (III) PORPHYRIN : A MODEL REACTION OF OXYGEN ACTIVATION MECHANISM IN CYTOCHROME P-450
- In Vivo Nitric Oxide Production and iNOS Expression in X-Ray Irradiated Mouse Skin(Miscellaneous)
- Diabetes Mellitus Associated with Klinefelter's Syndrome : A Case Report and Review in Japan
- The alteration of chondrules and matrices in new Antarctic carbonaceous chondrites
- MODEL REACTIONS RELATED TO METALLOPORPHYRINS IN BIOLOGICAL SYSTEMS : REACTION OF METALLOPORPHYRINS WITH SUPEROXIDE ION
- Kinetic Studies on the Autoxidation of Cysteine Catalyzed by Copper Complexes : Catecholamines Stimulate the Autoxidation
- CAN COPPER (II) COMPLEXES ACTIVATE HYDROGEN PEROXIDE? : ESR-SPIN TRAPPING STUDIES
- Evidence for the Formation of Hydroxyl Radical from the Reactions of Some Copper (II) Complexes with Hydrogen Peroxide
- Intracranial Malignant Lymphoma developing 20 Years after Total Removal of Testicular Malignant Lymphoma : -Case Report-
- Lack of Association between IL-12B Gene Polymorphism and Autoimmune Thyroid Disease in Japanese Patients
- Distribution of Hydrogen Peroxide-dependent Reaction in a Gelatin Sample Irradiated by Carbon Ion Beam
- Interactions between Lactobacillus kefiranofaciens and Saccharomyces cerevisiae in Mixed Culture for Kefiran Production(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- MR Imaging of Articular Cartilage in Medial-Type Osteoarthritis of the Knee
- Cholecystoparesis with Diabetic Autonomic Neuropathy
- Petrology and mineralogy of the Yamato-86720 carbonaceous chondrite
- Oxygen isotopic compositions of petrographically described inclusions from Antarctic unequilibrated ordinary chondrites
- Pathologic Background of Abnormal Serum Amyloid A and Interleukin-6 Levels Revealed by a Piecewise Linear Regression Model in the Population of Diabetic Patients
- Application of In vivo Electron Spin Resonance (ESR) Spectroscopy for Oral Region of Small Animal Model
- High-Pressure Raman Study of Carbon Tetrafluoride up to 8 GPa
- Petrology of the Yamato-8449 CR chondrite
- Petrology of an unusual monomict ureilite, NWA1241
- A Study on MR images of the Articular Cartilage in Medial-Type Osteoarthritis of the Knee
- A Study on MR images of the Articular Cartilage in Medial-Type Osteoarthritis of the Knee
- Suppression of Tumor Growth in Experimental 9L Gliosarcoma Model by Copper Depletion
- Terrestrial alteration of Fe-Ni metals in Antarctic ordinary chondrites and the relationship to their terrestrial ages
- Vascular Endothelial Function and Reactive Oxygen Species Interaction in Lingual Artery
- Petrography and mineral compositions of the Yamato-7308 howardite
- Petrological and geochemical study of the Yamato-74359 and Yamato-74360 achondrites
- Roles of Collagen Molecules in Growth and Differentiation of Human Osteoblasts
- Anhydrous alteration of Allende chondrules in the solar nebula III: Alkali-zoned chondrules and heating experiments for anhydrous alteration
- Mineralogy and petrology of an unusual Belgica-7904 carbonaceouschondrite: Genetic relationships among the components
- Anhydrous alteration of Allende chondrules in the solar nebura II: Alkali-Ca exchange reactions and formation of nepheline,sodalite and Ca-rich phases in chondrules
- Anhydrous alteration of Allende chondrules in the solar nebura I: Description and alteration of chondrules with known oxygen-isotopic compositions
- Petrology of the Yamato 980459 shergottite
- Magmatic inclusions in martian meteorites
- Petrology of the Yamato-74442 Chondrite
- Synthesis and Enhanced Radical Scavenging Activity of a Conformationally Constrained Epigallocatechin Analogue
- Kinetics and Mechanism for the Scavenging Reaction of the 2, 2-Diphenyl-1-picrylnydrazyl Radical by Synthetic Artepillin C Analogues
- Fasudil Suppresses Fibrosarcoma Growth by Stimulating Secretion of the Chemokine CXCL14/BRAK
- Spin-trapping of alkyl radicals by a water-soluble nitroso aromatic spin-trap, 3,5-dibromo-4-nitrosobenzenesulfonate.
- Spin-Trapping of Selenium-Containing Inorganic Radicals in Aqueous Solutions.
- Joint Transmit/Receive MMSE-FDE for Analog Network Coded Single-Carrier Bi-directional Multi-Antenna Relay
- Fasudil Suppresses Fibrosarcoma Growth by Stimulating Secretion of the Chemokine CXCL14/BRAK