Diabetes Mellitus Associated with Klinefelter's Syndrome : A Case Report and Review in Japan
スポンサーリンク
概要
- 論文の詳細を見る
We report a case of Klinefelters syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelters syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47, XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelters syndrome in Japanese patients including this case.(Internal Medicine 41: 842-847, 2002)
- 社団法人日本内科学会の論文
- 2002-10-01
著者
-
Suehiro Tadashi
大阪大学 医学系研究科循環器内科学
-
Suehiro Tadashi
大阪府立大学 総合リハビリテーション学部理学療法学
-
Kumon Yoshitaka
大阪大学 医学系研究科循環器内科学
-
Kumon Y
Department Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University
-
Sugimoto Taizou
大阪大学 医学系研究科
-
Ikeda Yukio
Department Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University
-
IKEDA Yukio
the Second Department of Internal Medicine, Tohoku University School of Medicine
-
Hashimoto Kozo
Department Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University
-
HASHIMOTO Kozo
the Second Department of Internal Medicine, Kochi Medical School
-
ARII KAORU
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University
-
OTA Kikuko
the Second Department of Internal Medicine, Kochi Medical School
-
SUEHIRO Tadashi
the Second Department of Internal Medicine, Kochi Medical School
-
ARII Kaoru
the Second Department of Internal Medicine, Kochi Medical School
-
KUMON Yoshitaka
the Second Department of Internal Medicine, Kochi Medical School
-
Shiinoki Tomoko
Second Department Of Internal Medicine Kochi Medical School
-
Suehiro Tadashi
The Second Department Of Internal Medicine Kochi Medical School
-
Arii Kaoru
Department Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University
-
Ota Kikuko
The Second Department Of Internal Medicine Kochi Medical School
-
Hashimoto K
Kochi Medical School Kochi Jpn
-
Hashimoto Kozo
Second Department Of Internal Medicine Kochi Medical School
-
Hashimoto Kozo
The Second Department Of Internal Medicine
-
Hashimoto Kozo
The Second Department Of Internal Medicine Kochi Medical School
-
Ota Kikuo
the Second Department of Internal Medicine, Kochi Medical School
関連論文
- Three Cases of Gitelman's Syndrome Possibly Caused by Different Mutations in the Thiazide-Sensitive Na-Cl Cotransporter
- Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement
- Hormonal Regulation of Glycolytic Enzyme Gene and Pyruvate Dehydrogenase Kinase/Phosphatase Gene Transcription
- Major-element trend for shergottite melts and their source materials
- Plasma Adiponectin Levels are Increased Despite Insulin Resistance in Corticotropin-releasing Hormone Transgenic Mice, an Animal Model of Cushing Syndrome
- Crohn's Disease Associated with Growth Hormone Secretory Dysfunction
- Insulin Enhancement of Cytokine-Induced Coagulation/Inflammation-Related Gene Transcription in Hepatocytes
- Lipopolysaccharide Stimulates Proopiomelanocortin Gene Expression in AtT20 Corticotroph Cells
- Effect of corticosterone on ghrelin messenger ribonucleic acid expression in the rat stomach
- Physiological Roles of Corticotropin - Releasing Hormone Receptor Type 2
- High Glucose Induces Transactivation of the α2-HS Glycoprotein Gene Through the ERK1/2 Signaling Pathway
- Muscle Strength is a Marker of Insulin Resistance in Patients with Type 2 Diabetes : A Pilot Study
- Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes
- Diabetes Mellitus Associated with Klinefelter's Syndrome : A Case Report and Review in Japan
- Serum Paraoxonase(PON1) Concentration in Patients Undergoing Hemodialysis
- A Polymorphism in the Promoter Region of the Glucocorticoid Receptor Gene Is Associated with Its Transcriptional Activity
- Clinical Significance of the Insulin Resistance Index as Assessed by Homeostasis Model Assessment
- Serum Paraoxonase and Arylesterase Activities in Hemodialysis Patients
- Urinary prostacyclin metabolites in patients with IgA nephropathy
- Severe Diabetic Scleredema with Extension to the Extremities and Effective Treatment Using Prostaglandin E_1
- Trp64Arg Mutation of β_3-Adrenergic Receptor and Insulin Sensitivity in Subjects with Glucose Intolerance
- Simple Obesity with Cardiomyopathy of Obesity
- A Novel Nonsense Mutation in Exon 1 and a Transition in Intron 3 of the Lipoprotein Lipase Gene
- Hypothyroidism Preceding Hyperthyriodism in a Patient with Continuously Positive Thyroid Stimulating Antibody
- Anti-Alpha-Enolase Antibodies in Pituitary Disease
- Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA)
- Development and Validation of a 0.5mg Dexamethasone Suppression Test as an Initial Screening Test for the Diagnosis of ACTH-dependent Cushing's Syndrome
- Periodic Secretion of Adrenocorticotropin in a Patient with Cushing's Disease Manifested during Pregnancy
- Chronic Lupus Peritonitis with Massive Ascites at Elderly Onset : Case Report and Review of the Literature
- Non-Insulin-Dependent Diabetes Mellitus Complicated with Idiopathic Hypoparathyroidism.
- Hemangioblastomas with Blood Supply from the Dural Arteries : Two Case Reports
- Scalp Hair Loss Caused by Octreotide in a Patient with Acromegaly : A Case Report
- Petrology of a new basaltic shergottite: Dhofar 378
- Antarctic howardites and their primitive crust
- Chemical compositions of matrices of unequilibrated ordinary chondrites
- Fatal Severe Vasospasm Due to Rewarming Following Hypothermia
- A Rare Case of Cushing's Syndrome due to Bilateral Adrenocortical Adenomas
- Comparative study on the major element chemical compositions of Antarctic chondrites to those of non-Antarctic falls with reference to terrestrial weathering
- Yamato nakhlites: Petrography and mineralogy
- Petrology and chemistry of the Miles IIE iron. II: Chemical characteristics of the Miles silicate inclusions
- Petrology and chemistry of the Miles IIE iron. I: Description and petrology of twenty new silicate inclusions
- Yamato-791093, a metal-sulfide-enriched H-group chondritic meteorite transitional to primitive IIE irons with silicate inclusions
- New enclaves in the Vaca Muerta mesosiderite: Petrogenesis and comparison with HED meteorites
- Enclaves in the Mt.Padbury and Vaca Muerta mesosiderites: Magmatic and residue (or cumulate) rock types
- Mineralogy of Antarctic aubrites, Yamato-793592 and Allan Hills-78113: Comparison with non-Antarctic aubrites and E-chondrites
- Petrology of silicate inclusions in the Miles IIE iron
- Lithic and mineral clasts in the Dar Al Gani (DAG) 319 polymict ureilite
- Mutations in Exon 7 of the GTP-Binding Protein G_sα Were Not a Common Cause of Pseudohypoparathyroidism with Albright's Hereditary Osteodystrophy in Japanese
- Assessment of Oxidative Stress in the Spontaneously Hypertensive Rat Brain Using Electron Spin Resonance (ESR) Imaging and in Vivo L-Band ESR
- Measurement of Oxidative Stress in the Rodent Brain Using Computerized Electron Spin Resonance Tomography
- Effects of proinfl ammatory cytokines on intracellular glucocorticoid metabolism
- Short-Term Effects of Octreotide on Glucose Tolerance in Patients with Acromegaly
- Abrupt-Onset Diabetes Mellitus in the Elderly
- A Case of Gitelman's Syndrome with Chondrocalcinosis
- Diabetes Mellitus Associated with Klinefelter's Syndrome : A Case Report and Review in Japan
- The alteration of chondrules and matrices in new Antarctic carbonaceous chondrites
- Intracranial Malignant Lymphoma developing 20 Years after Total Removal of Testicular Malignant Lymphoma : -Case Report-
- Erdheim-Chester Disease : Report of a Case with PCR-based Analysis of the Expression of Osteopontin and Survivin in Xanthogranulomas Following Glucocorticoid Treatment
- Lack of Association between IL-12B Gene Polymorphism and Autoimmune Thyroid Disease in Japanese Patients
- A Case of Lymphocytic Infundibuloneurohypophysitis Associated with Systemic Lupus Erythematosus
- Possible Reproductive Toxicity of Styrene in Peripubertal Male Mice
- A Case of Lymphocytic Infundibuloneurohypophysitis Showing Diabetes Insipidus Followed by Anterior Hypopituitarism Associated with Thrombasthenia
- Chronic Lupus Peritonitis with Massive Ascites at Elderly Onset : Case Report and Review of the Literature
- Secretion of Anterior Pituitary Hormones in Patients with Insulin-Dependent Diabetes Mellitus and Polyglandular Autoimmune Syndrome
- Hypothalamic-Pituitary-Adrenal Axis in WBN/Kob Rats with Non-Insulin Dependent Diabetes Mellitus
- Nitric Oxide Plays No Role in ACTH Release Induced by Interleukin-1β, Corticotropin-Releasing Hormone, Arginine Vasopressin and Phorbol Myristate Acetate in Rat Pituitary Cell Cultures
- Cholecystoparesis with Diabetic Autonomic Neuropathy
- The Etiology of Isolated Thyroid Stimulating Hormone Deficiency
- Lymphocytic Adenohypophysitis and Lymphocytic Infundibuloneurohypophysitis
- Corticotropin-releasing hormone (CRH) transgenic mice display hyperphagia with increased Agouti-related protein mRNA in the hypothalamic arcuate nucleus
- Evaluation of Plasma, Salivary, and Urinary Cortisol Levels for Diagnosis of Cushing's Syndrome
- PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
- Hormonal Regulation of Acetyl-CoA Carboxylase Isoenzyme Gene Transcription
- Weber-Christian disease associated with granulomatous mastitis : a variant type of Weber-Christian disease?
- ^FDG PET/CT is a powerful tool for detecting subclinical arthritis in patients with psoriatic arthritis and/or psoriasis vulgaris
- Insulin Resistance in a Patient with Diabetes Mellitus Associated with Turner's Syndrome
- Primary Low Cerebrospinal Fluid Pressure Syndrome Associated with Galactorrhea.