Secretion of Anterior Pituitary Hormones in Patients with Insulin-Dependent Diabetes Mellitus and Polyglandular Autoimmune Syndrome
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概要
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We extracted gammaglobulins from the serum of 10 patients with insulin-dependent diabetes mellitus (IDDM) to investigate their effect on anterior pituitary hormone secretion using cultures of rat anterior pituitary cells. Three of the 10 patients also had the polyglandular autoimmune syndrome (PGA) type III with an isolated failure of anterior pituitary hormone secretion. The gammaglobulin from each of the 3 patients with PGA and an isolated failure of secretion of adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH) or gonadotropin inhibited the secretion of ACTH, TSH or gonadotropin in cultures of rat anterior pituitary cells. The gammaglobulins obtained from the other 7 patients with IDDM also showed an inhibitory or stimulatory effect on anterior pituitary hormone secretion in vitro. We postulate that some patients with IDDM, especially those with other endocrine autoimmune diseases, may have substances in their gammaglobulin fraction that can affect the secretion of anterior pituitary hormones.(Internal Medicine 35: 686-692, 1996)
- 社団法人 日本内科学会の論文
著者
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Noguchi T
Setsunan Univ. Osaka
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HASHIMOTO Kozo
the Second Department of Internal Medicine, Kochi Medical School
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TAKAO TOSHIHIRO
The Second Department of Internal Medicine, Kochi Medical School
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Kurokawa Hisayo
The Second Department Of Internal Medicine Kochi Medical School
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Nishioka Tatsuya
The Second Department Of Internal Medicine Kochi Medical School
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Takao Toshihiro
Departments Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University
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Hashimoto Kozo
Second Department Of Internal Medicine Kochi Medical School
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Numata Yukiko
The Second Department Of Internal Medicine Kochi Medical School
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Hashimoto Kozo
The Second Department Of Internal Medicine
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Hashimoto Kozo
The Second Department Of Internal Medicine Kochi Medical School
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