Inhibition of γ-Radiation Induced DNA Damage in Plasmid pBR322 by TMG, a Water-soluble Derivative of Vitamin E
スポンサーリンク
概要
- 論文の詳細を見る
Alpha-tocopherol monoglucoside (TMG), a water-soluble derivative of α-tocopherol, has been examined for its ability to protect DNA against radiation-induced strand breaks. Gamma radiation, up to a dose of 6 Gy (dose rate, 0.7 Gy/ minute), induced a dose-dependent increase in single strand breaks (SSBs) in plasmid pBR322 DNA. TMG inhibited the formation of γ-radiation induced DNA single strand breaks (SSBs) in a concentration-dependent manner; 500μM of TMG protected the single strand breaks completely. It also protected thymine glycol formation induced by γ-radiation in a dose-dependent manner, based on an estimation of thymine glycol by HPLC.
- 日本放射線影響学会の論文
著者
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Krishnan Nair
Bhabha Atomic Res. Centre Mumbai Ind
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Kagiya Tsutomu
Health Res. Foundation Kinki Invention Centre
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Kagiya Tsutomu
Kinki Research Foundation
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Krishnan Nair
Radiation Biology And Health Sciences Division Bhabha Atomic Research Centre
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RAJAGOPALAN REMA
Radiation Biology Division, Bhabha Atomic Research Centre
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WANI KHALIDA
Department of Radiation Oncology, Nanavati hospital MRC, Vile Parle
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HUILGOL NAGARAJ
Department of Radiation Oncology, Nanavati hospital MRC, Vile Parle
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Wani Khalida
Department Of Radiation Oncology Nanavati Hospital Mrc Vile Parle
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Rajagopalan R
Bhabha Atomic Res. Centre Mumbai Ind
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Rajagopalan Rema
Radiation Biology And Health Sciences Division Bhabha Atomic Research Center
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Huilgol N
Department Of Radiation Oncology Nanavati Hospital Mrc Vile Parle
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