CD47 regulates the TGF-.BETA. signaling pathway in osteoblasts and is distributed in Meckel's cartilage
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概要
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Previously, CD47 gene expression has been shown to increase during mandible development using a micro array technique. To determine the function of CD47 in osteoblasts, CD47 was silenced using siRNA <I>in vitro</I>. The TGF-β1 and phosphorylated-Smad2 levels and transcription factor genes related to bone metabolism increased dose-dependently with CD47 silencing. Furthermore, we determined the distribution of CD47 in mouse embryonic E13 and E15 <I>in vivo</I>. The CD47-positive cells were localized in Meckel's cartilage and antenatal mandibular bone. These results suggest that TGF-β1 signaling and mandible development might be regulated by CD47. (J Oral Sci 53, 169-175, 2011)
- 日本大学歯学部の論文
著者
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Ito Koichi
Department of Periodontology, Nihon University School of Dentistry
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Ishibashi Kazuya
Department Of Cardiology Kyoto Prefectural Yosanoumi Hospital
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IKEDA Kyoko
Department of Cardiology, St. Marianna University School of Medicine
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Nakajima Akira
Department Of Applied Electronics Tokyo Institute Of Technology
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Shimizu Noriyoshi
Department Of Orthodontics Nihon University School Of Dentistry
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Ito Koichi
Department Of Biomedical Sciences Hirosaki University Graduate School Of Health Sciences
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NAKAJIMA Akira
Department of Orthodontics, Nihon University School of Dentistry
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Shimada Koichi
Department of Periodontology, Nihon University School of Dentistry
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Ikeda Kyoko
Department of Periodontology, Nihon University School of Dentistry
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