Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Masasa fascicularis)
スポンサーリンク
概要
- 論文の詳細を見る
ELOVL4, elongation factor of very long chain fatty acids-4, is known to be responsible for autosomal dominant macular degeneration and Stargardt-like macular degeneration. In this study, we cloned the monkey homologue of ELOVL4 and determined the cellular and tissue distribution of the gene product. Sequence analysis of the monkey ELOVL4 gene revealed a high degree of homology between human and monkey. The cloned full-length cDNA of monkey ELOVL4 encoded 314 amino acids, the same length as human and two amino acids longer than mouse. The monkey ELOVL4 conserved the characteristics typical of the super family of ELO enzymes involved in the metabolism of membrane-bound fatty acid elongation. Real-time quantitative PCR demonstrated that the monkey ELOVL4 gene was highly expressed in restricted tissue-specific fashion, not only in the retina but also in the skin (90% of retina) and thymus (111% of retina). Immunohistochemical analysis detected signals predominantly in the photoreceptor layer of the monkey retina.
- 社団法人 日本実験動物学会の論文
- 2003-04-01
著者
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FUJIKI Keiko
Department of Ophthalmology, Juntendo University School of Medicine
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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Fujiki Keiko
順天堂大学 医学研究科眼科学
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Fujiki Keiko
順天堂大学 眼科
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Fujiki Keiko
Department Of Biology Faculty Of Science Kumamoto University
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Yoshikawa Yasuhiro
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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ONO Fumiko
The Corporation for Production and Research of Laboratory Primates
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Fujiki K
Department Of Ophthalmology Juntendo University School Of Medicine
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KANAI Atsushi
Department of Ophthalmology, Juntendo University School of Medicine
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Kobayashi Akira
National Agricultural Research Center for Hokkaido Region
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IWATA Takeshi
National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
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Akeo K
Department Of Ophthalmology Of Keio University School Of Medicine
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Kanai A
Department Of Ophthalmology Juntendo Tokyo Koto Geriatric Medical Center
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Kanai A
Ntt Corp. Musashino‐shi Jpn
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IWATA Fumino
Department of Ophthalmology, Juntendo University School of Medicine
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Suzuki T.
The Corporation For Production And Research Of Laboratory Primates
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Suzuki Michihiro
The Corporation For Production And Research Of Laboratory Primates
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UMEDA Shinsuke
National Institute of Sensory Organs, National Tokyo Medical Center
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AYYAGARI Radha
Department of Opthalmology, Kellogg Eye Center, University of Michigan
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TAKADA Yuichiro
Department of Opthalmology, Kellogg Eye Center, University of Michigan
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TANAKA Yasuhiko
National Institute of Sensory Organs, National Tokyo Medical Center
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Yoshikawa Yasuhiro
School Of Agricultural And Life Sciences University Of Tokyo
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Iwata Fumino
Department Of Ophthalmology Juntendo University School Of Medicine
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Iwata Takeshi
Div. Of Molecular & Cellular Biology National Inst. Of Sensory Organs National Hospital Organiza
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Kanai Atsushi
Department Of Ophthalmology Juntendo Tokyo Koto Geriatric Medical Center
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Kanai A
Department Of Ophthalmology Juntendo University School Of Medicine
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Umeda Shinsuke
Div. Of Molecular & Cellular Biology National Inst. Of Sensory Organs National Hospital Organiza
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Ayyagari Radha
Department Of Opthalmology Kellogg Eye Center University Of Michigan
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Kobayashi A
National Agricultural Research Center For Hokkaido Region
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Takada Yuichiro
Department Of Ophthalmology Jikei University School Of Medicine:department Of Pathology Tokyo Women&
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Takada Yuichiro
Department Of Opthalmology Kellogg Eye Center University Of Michigan
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Fujiki K
Juntendo Univ. School Of Medicine Tokyo Jpn
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Iwata Takeshi
National Eye Institute National Institutes Of Health Bethesda Maryland Usa
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Tanaka Yasuhiko
National Institute Of Sensory Organs National Tokyo Medical Center
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Fujimaki T
Department Of Ophthalmology Juntendo University School Of Medicine
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