ユビキチンのC末端加水分解酵素欠損は骨石灰化を減少させる(生理学)
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概要
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ユビキチンのC末端加水分解酵素L1(UCH-L1)は,ユビキチン・プロテアソーム系のコンポーネントであり独特な生物活性を示す.本研究では,UCH-L1の発現様式と骨新生における骨石灰化の調節への関与について報告する.UCH-L1は,造骨細胞,破骨細胞と大腿骨骨端及び骨幹部の骨髄造血幹細胞に発現していた.UCH-L1の骨石灰化への関与を調べるため,gadマウス(UCH-L1欠損マウス)を用いて骨密度(BMD)をコンピューター断層撮影法で調べた.雄gadマウスでは大腿骨全般に低石灰化が観察された.これらの結果から,UCH-L1機能が骨生成時の骨石灰化調節に関わっていることが示唆される.
- 社団法人日本獣医学会の論文
- 2008-06-25
著者
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YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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KWON Young-Bae
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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KWON Jungkee
Department of Biomedical Science Graduate School of Agricultural and Life Sciences, The University o
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Kwon Jungkee
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Kwon Jungkee
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Chonbuk National University
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Kwon Young-bae
Department Of Pharmacology Institute For Medical Science Chonbuk National University
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Yoshikawa Yasuhiro
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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SHIM Sehwan
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National Universit
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Shim Sehwan
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Chonbuk National University
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Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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吉川 泰弘
Dep. Of Biomedical Sci. Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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