はち毒を使用した經穴刺激は,ホルマリンによって引き起こされるラットの痛覚行動と脊髄でのFos発現を減少させる
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概要
- 論文の詳細を見る
經穴へのはち毒(BV)の注射が,マウスの内臓痛覚モデルおよびラットの慢性関節炎モデルの両方で,有意な抗痛覚と抗炎症性作用を示すことを既に報告した.本研究では,ホルマリン注射でラットに誘起される脊髄のFos発現を伴う痛覚反応に対するBV前処置の影響を検討した.成熟Spraguc-Dawleyラットの足三里(Zusanli, ST36)經穴,あるいは背部の經穴ではない任意の部位にBVを注射した.足三里へのBV前投与は,ホルマリン・テストの後半に観察される足をなめる時間を減少させた.対照的に背部の非經穴にBVを投与した場合には,足をなめる時間は影響されなかった.さらに,足三里へのBV前投与は,ホルマリン注入によって引き起こされる脊髄Fos発現を著しく抑制した.以上の結果から,足三里へのBV前処置がホルマリンによって引き超こされる痛覚反応に拮抗する効果のあることが明らかとなった.
- 社団法人日本獣医学会の論文
- 2003-03-25
著者
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Lee Han-chang
Department Of Meridian And Acupuncture College Of Oriental Medicine Kyung Hee University
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Lee Jang-hern
Department Of Veterinary Physiology College Of Veterinary Medicine And School Of Agricultural Biotec
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Han Ho-jae
Hormone Research Center College Of Veterinary Medicine Chonnam National University
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Yang Ii-suk
Department Of Veterinary Physiology College Of Veterinary Medicine And School Of Agricultural Biotec
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KIM Hyun-Woo
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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KWON Young-Bae
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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HAM Tae-Won
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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ROH Dae-Hyun
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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YOON Seo-Yeon
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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LEE Hye-Jung
Graduate School of East-West Medical Science, Kyung Hee University
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YANG Il-Suk
Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biote
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BEITZ Alvin
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota
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Lee Hye-jung
Acupuncture And Meridian Science Research Center Kyung Hee University
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Lee Hye-jung
Acupuncture & Meridian Science Research Center Kyung-hee University:institute Of Oriental Medici
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Lee Hye-jung
Graduate School Of East-west Medical Science Kyunghee University
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Lee H‐j
Department Of Meridian And Acupuncture College Of Oriental Medicine Kyung Hee University
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Kwon Young-bae
Department Of Pharmacology Institute For Medical Science Chonbuk National University Medical School
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Lee Jang-hern
Department Of Veterinary Physiology College Of Veterinary Medicine And Bk21 Program For Veterinary S
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Kwon Young-bae
Korea Institute Of Machinery And Materials
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Kwon Young-bae
Department Of Pharmacology Institute For Medical Science Chonbuk National University
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Lee J‐h
Chonnam National Univ. Kor
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YOON Seo-Yeon
Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University
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Roh Dae-hyun
Department Of Veterinary Physiology College Of Veterinary Medicine And Bk21 Program For Veterinary S
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Lee John
Laboratories Of Public Hygiene College Of Veterinary Medicine And Bio-safety Research Institute Chon
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Lee Ju-hyun
Department Of Veterinary Physiology College Of Veterinary Medicine And Bk21 Program For Veterinary S
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Ham Tae-won
Department Of Veterinary Physiology College Of Veterinary Medicine And School Of Agricultural Biotec
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Yoon Seo-yeon
Biotherapy Human Resources Center College Of Veterinary Medicine Chonnam National University
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Beitz Alvin
Department Of Veterinary And Biomedical Sciences College Of Veterinary Medicine University Of Minnes
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Kim Hyun-woo
Department Of Veterinary Physiology College Of Veterinary Medicine And Bk21 Program For Veterinary S
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Kim Hyun-woo
Process Development Team Semiconductor R&d Center Samsung Electronics Co. Ltd.
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Kim Hyun-woo
Department Of Biology Pusan National University
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Lee H.-j.
Acupuncture And Meridian Science Research Center (amsrc) Kyung Hee University
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Roh Dae-Hyun
Department of Maxillofacial Tissue Regeneration and Research Center for Tooth and Periodontal Tissue Regeneration, School of Dentistry, Kyung Hee University
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Ham Tae-Won
Department of Chemical Engineering, Dong-A University
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