Neuroprotective Effect of Palmul-Chongmyeong-Tang on Ischemia-Induced Learning and Memory Deficits in the Rat(Pharmacognosy)
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概要
- 論文の詳細を見る
Ginseng Radix, Atractylodis Macrocephalae Rhizoma, Poria, Glycyrrhizae Radix, Angelicae Gigantis Radix, Ligusticum Rhizoma, Rehmanniae Radix, Paeoniae Radix, Acori Graminei Rhizoma, and Polygalae Radix have been widely used as herbal medicine against ischemia. In order to test the neuroprotective effect of a novel prescription, the present study examined the effects of Palmul-Chongmyeong-Tang (PMCMT) consisting of these ten herbs on learning and memory in the Morris water maze task and the central cholinergic system of rats with cerebral ischemia-induced neuronal and cognitive impairments. After middle cerebral artery occlusion (MCAO) for 2h, rats were administered with saline or PMCMT (200mg/kg, p.o.) daily for 2 weeks, followed by their training to the tasks. In the water maze test, the animals were trained to find a platform in a fixed position during 6d and then received a 60s probe trial on the 7th day following removal of the platform from the pool. Rats with ischemic insults showed impaired learning and memory of the tasks and treatment with PMCMT produced a significant improvement in escape latency to find the platform in the Morris water maze. Consistent with behavioral data, treatment with PMCMT also reduced the loss of cholinergic immunoreactivity in the hippocampus induced by cerebral ischemia. These results demonstrated that PMCMT has a protective effect against ischemia-induced neuronal and cognitive impairments. The present study suggested that PMCMT might be useful in the treatment of vascular dementia.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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Lee Han-chang
Department Of Meridian And Acupuncture College Of Oriental Medicine Kyung Hee University
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LEE Hye-Jung
Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University
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KANG Sung-Keel
Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University
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Lee Hye-jung
Acupuncture & Meridian Science Research Center Kyung-hee University:institute Of Oriental Medici
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Hahm Dae-hyun
Acupuncture And Meridian Science Research Center Kyung Hee University
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Hahm Dae-hyun
Acupuncture & Meridian Science Research Center Kyung-hee University:institute Of Oriental Medici
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Lee H‐j
Department Of Meridian And Acupuncture College Of Oriental Medicine Kyung Hee University
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SHIM Insop
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Yun Young-ju
Department Of Life Science Sookmyung Women's University
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Han Seung-moo
Department Of Biomedical Engineering Kyung Hee University
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Kang Sung-keel
Department Of Acupuncture And Moxibustion College Of Oriental Medicine Kyung Hee University
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Shim Insop
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Shim Insop
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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PYUN Kwang-Ho
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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HAHM Dae-Hyun
Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee Univ
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LEE BomBi
Department of Neurobiology, Division of Neuroscience, Children's Hospital and Harvard Medical School
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Hahm Dae-hyun
Institute Of Oriental Medicine College Of Korean Medicine Kyung Hee University
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Pyun Kwang-ho
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Lee H.-j.
Acupuncture And Meridian Science Research Center (amsrc) Kyung Hee University
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Lee Bombi
Department of Neurobiology, Division of Neuroscience, Children's Hospital and Harvard Medical School
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